Synthesis and characterization of Mn(II),Co(II),Ni(II),Cu(II) and Zn(II) complexes with N-(4-phenylthiazol-2-yl)benzamide and evaluation of its biological activity

Saeed, Farah Tariq

doi:10.33899/rjs.2025.163153.1496

	Synthesis and characterization of Mn(II),Co(II),Ni(II),Cu(II) and Zn(II) complexes with N-(4-phenylthiazol-2-yl)benzamide and evaluation of its biological activity
Rafidain Journal of Science
Articles in Press, Accepted Manuscript, Available Online from 21 September 2025
Document Type: Research Paper
DOI: 10.33899/rjs.2025.163153.1496
Author
Farah tariq saeed^*
Dept. of Chem., College of Science, Mosul University
Abstract
For the synthesis of the new N-(4-phenylthiazol-2-yl) benzamide ligand, 4-phenylthiazol-2-amine, and benzoyl chloride in a 1:1 molar ratio were condensed in ethanol with ammonium acetate. For creating the Zn(II), Ni(II), Mn(II), and Co(II) complexes, the above mentioned ligand was directly reacted with metal chlorides in an ethanolic medium at a molar ratio of either 1:1 or 2:1 (Ligand:metal). Determination of the elemental composition of a substance, spectral studies (FTIR, UV/visible), Proton-NMR measurements, conductivity measurements, and electronic spectra values were used to characterize the prepared complexes. The results showed octahedral and tetrahedral geometric availability near the metal ions, as well as an inhibiting impact on the proliferation of different bacterial types, including strains of Bacillus , Staphylococcus aurous, Klebsiella pneumonia and Escherichia coli. According to the results, complex (9) has a greater impact on various bacterial ( Bacillus , Staphylococcus aurous, Klebsiella pneumonia)species than the other complexes, which had a lower effectiveness rate.
Keywords
Triazole; complexes; transition metal; ligand

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