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Prevalence of Virulence Factors and Antimicrobial Resistance AmongPseudomonas Aeruginosa Isolated from Different Clinical Sources in Mosul City | ||
| Rafidain Journal of Science | ||
| Articles in Press, Accepted Manuscript, Available Online from 21 September 2025 | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rjs.2025.161955.1477 | ||
| Author | ||
| Vian Omer Al-Mazouri* | ||
| Al-Shekhan Education Directorate | ||
| Abstract | ||
| The pathogenic bacteria "Pseudomonas aeruginosa" considered opportunistic pathogen and critically very dangerous for people suffering from immune disorder because it has different complex virulence factors and can resist several classes of antibiotics. Between October 2024 and February 2025, 150 specimens were taken from various clinical conditions, such as burns, midstream urine, wounds, ears, noses, throats, and sputum. From 150 clinical specimens, only 36 isolates (24%) of P. aeruginosa were identified by cultural characteristics, a biochemical test, and by Vitek 2-Compact system which include (5(41.6%),3(8.3%),2(5.52%) from burn infections, ear and nasal specimens respectively, while isolated at same number and percentage at 5(13.8%) from wound, sputum and urine samples. The antibiotic sensitivity test was performed for all isolates and the results showed the highest resistance percentages were for, tobramycin, amoxicillin-clavulanic acid, ceftazidime and ciprofloxacin at 83.3%,77.7 75% and 72.2% respectively while the lowest resistance percentage were for the meropenem and imipinem at 25% and 13.8% respectively. thirteen (36.1%) of the isolates were categorized as MDR. all isolates at 100% produced the extended spectrum Beta-lactamaces,35 isolates produced the AmpC Beta-lactamases, while 23 isolates produced the Beta-lactamases The production percentages of virulence factors determined in all selected isolates which were 100% for biofilm formation, while the percentages production of rest virulence factors was at (83.3%) for hemolysin and protease, 75%,72. %,63.8%,41.6% for the lecithinase, lipase, gelatinase and slime layer respectively. | ||
| Keywords | ||
| Antibiotics resistance; Beta lactamase; Pseudomonas aeruginosa; Virulence factor | ||
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