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Mediastinal Plexiform Neurofibroma Presenting as Asthma in a Patient with Neurofibromatosis Type 1: A Case Report | ||
| Al- Anbar Medical Journal | ||
| Volume 21, Issue 4, October 2025, Pages 290-294 PDF (4.15 M) | ||
| Document Type: Original articles | ||
| DOI: 10.33091/amj.2025.161958.2304 | ||
| Authors | ||
| Shaymaa Khalid Abdulqader* 1; Nabeeha Najatee Akram2; Samar ahmed jasim3; Tarik M. Abdul Majeed Al-Bermani4; Wassan Nori Mohammed Hassan5 | ||
| 1Department of Surgery/Radiology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq | ||
| 2Department of Paediatrics, College of Medicine, Mustansiriyah University, Baghdad, Iraq | ||
| 3Department of Medicine/Dermatology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq | ||
| 4Respiratory Unit, Al-Karama Hospital, Al-Karkh Health Directorate, Baghdad, Iraq | ||
| 5Department of Gynaecology and Obstetrics, College of Medicine, Mustansiriyah University, Baghdad, Iraq | ||
| Abstract | ||
| Plexiform neurofibroma (PN) is a pathognomonic feature of neurofibromatosis type 1 (NF1). When the clinical manifestations of NF1 are unrecognized and PN develops in deep anatomical locations, diagnosis may be delayed until the tumor is large enough to compress adjacent structures. We report a case of PN in which delayed recognition of NF1 led to years of misdiagnosis. A 27-year-old female with a history of poorly controlled asthma and a bizarre, lobulated opacity on chest X-ray had experienced respiratory symptoms since her early twenties, initially diagnosed with asthma at age 22. Despite multiple courses of antibiotics, bronchodilators, and steroids, her symptoms persisted. Computed tomography (CT) revealed a lobulated mass encasing the bronchial tree and pulmonary vessels, consistent with PN. The combination of a positive family history and a thorough physical examination is a cornerstone in the diagnostic process, ultimately establishing the diagnosis of NF1. This case underscores the crucial importance of a comprehensive clinical examination in the early recognition of PN and NF1. | ||
| Keywords | ||
| Café au lait spots; Plexiform neurofibroma; Neurofibromatosis type 1; Case report; Asthma | ||
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