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Protective Effects of Hibiscus sabdariffa L. Against Chlorpyrifos-Induced Thyroid Dysfunction: A Comparative Study of Antioxidant Efficacy | ||
| Basrah Journal of Veterinary Research | ||
| Article 6, Volume 24, Issue 3, September 2025, Pages 61-75 PDF (1.25 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvr.2025.158789.1212 | ||
| Authors | ||
| Mortada E Sadiq* 1; Muhsin S. G. Al-Mozie’l2; ASia Selman Abdullah3 | ||
| 1College of Pharmacy, University of Basra, Basra, Iraq | ||
| 2Department of pharmacology and toxicology, college of pharmacy, Basrah University, basra, Iraq | ||
| 3Department of pharmacology and toxicology, college of pharmacy, Basrah University, Basra, Iraq | ||
| Abstract | ||
| Hibiscus sabdariffa L. calyces (H. sabdariffa), widely consumed as a herbal tea, are recognized for their rich content of antioxidant phytochemicals and associated therapeutic properties. This study aimed to evaluate the potential protective effects of H. sabdariffa extract on thyroid function under conditions of oxidative stress induced by chlorpyrifos (CPF) exposure. A total of thirty rats were randomly assigned to five groups. The control group (G1) received no treatment. Group (G2) was administered CPF at a dose of 10 mg/kg/day. Groups (G3) and (G4) received H. sabdariffa extract at doses of 250 mg/kg and 750 mg/kg, respectively, in combination with CPF. Group (G5) received vitamin C at a dose of 100 mg/kg along with CPF. All treatments were administered orally for 28 days. At the end of the experimental period, blood samples were collected to assess serum levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). Additionally, thyroid tissues were collected for histopathological examination. The results demonstrated that groups G3, G4, and G5 exhibited no significant alterations in thyroid hormone levels compared to the control group, whereas G2 showed a significant reduction in T3, T4, and TSH levels. Histological findings further supported these results, revealing notable improvements in thyroid architecture compared to G2. In conclusion, the findings suggest that H. sabdariffa extract exerts a protective effect against CPF-induced oxidative damage to the thyroid gland. Its efficacy was comparable to that of vitamin C. Moreover, no significant difference was observed between the two administered doses of H. sabdariffa extract. | ||
| Keywords | ||
| Hibiscus sabdariffa L, Oxidative Stress; Thyroid Hormones | ||
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