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Changes in Peripapillary Perfusion and Retinal Nerve Fiber Layer in Diabetic Iraqi Patients | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 4, Volume 25, Issue 1, January 2026, Pages 20-27 PDF (1.11 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.52573/ipmj.2025.155402 | ||
| Authors | ||
| Rand Salman abdulghani* 1; Najah Kadhum Mohammed2 | ||
| 1ministry of health/ Baghdad Health Directorate_ Rusafa /Al Imam Ali hospital Baghdad/ Iraq | ||
| 2department of ophthalmology, faculty of medicine, Baghdad college of medicine Baghdad/ Iraq | ||
| Abstract | ||
| Background: Diabetic retinopathy (DR) is a leading cause of acquired blindness through retinal microvascular and neurodegenerative changes. Studying peripapillary vascular density (PPVD) through Optical coherence tomography and angiography (OCT & OCTA) imaging can offer insight into the effect of these changes and aid in management. Aim of the study: To assess the correlation between peripapillary retinal nerve fiber layer (PRNFL) thickness and peripapillary region perfusion through vascular density in various stages of diabetic retinopathy. Patients and methods: This is a comparative case–control study. Participants underwent an optic nerve head OCT and OCTA to measure PRNFL thickness, and peripapillary vascular density (PPVD) using the Triton ® Topcon device. Patients’ DR was classified according to the Early Treatment Diabetic Retinopathy Study (EDTRS) classification. Results: This study enrolled 95 participants: 28 controls (56 eyes) and 67 diabetic patients (123 eyes), a total of 179 eyes. The PRNFL thickness showed no statistically significant differences among study groups. The average PPVD was significantly lower in severe non-proliferative DR / neovascularization elsewhere (NPDR/ NVE) group compared to all other groups. Conclusion: Peripapillary vascular density correlated significantly with DR severity, decreasing with increasing DR severity. The PRNFL thickness showed no significant decrease neither correlating with DR severity nor PPVD. | ||
| Keywords | ||
| Diabetic retinopathy; Optical coherence tomography angiography; peripapillary vascular density | ||
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