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The Evaluation of circulating micro RNA-21 As a potential Biochemical in Women with Breast Cancer | ||
| Al-Zahraa Journal for Health and Medical Sciences | ||
| Article 5, Volume 3, Issue 3, September 2025, Pages 64-80 PDF (868.63 K) | ||
| Document Type: Research Article | ||
| Authors | ||
| Nawar Sameer Mohammed* 1; Wafaa Thaer Hatem2 | ||
| 1university of Baghdad | ||
| 2Biochemistry Department / College of Medicine/ University of Baghdad- Baghdad- Iraq | ||
| Abstract | ||
| Background: Breast carcinoma, a malignant neoplasm originating from breast tissue, exhibits a remarkable pathological diversity that underscores its complexity. However, the pathological manifestations of this disease are multifaceted, encompassing various histological subtypes and molecular classifications. In 2018, over 2 million new cases of breast cancer were estimated to occur globally, accounting for nearly 12% of all new cancer cases. Circular RNAs (microRNAs) have recently gained attention as a novel class of non-coding RNAs with diverse gene regulatory functions among the various epigenetic regulators. Subjects and methods: The study includes 100 women with age range 23 to 80 years old. They were divided into two groups: Group A include 48 women with newly diagnosis breast cancer. And group B include 52 women without breast cancer or any others cancers. Laboratory investigation included measurement of miR-21, CA 15-3, HbA1c, Lipid profile, liver function, renal function. Results: The mean ± SD for women without breast cancer was 8.64 ± 2.17, while for women with breast cancer patients, it was 46.32 ± 11.28. The p-value was 0.000, indicating statistical significance. In conclusion, our study proven an increase in micro RNA-21 with breast cancer compared to individuals without cancer. Micro RNA-21 used as biochemical marker for breast cancer. CA 15-3, also increased with the presence of breast cancer. | ||
| Keywords | ||
| microRNA-21; Breast cancer; Metastasis; CA 15-3; CEA | ||
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