Synthesis and Bioactivity of new complexes containing multi-substituted aryl imidazole as ligands

Khudair, Howraa; Abbas, Sawsan; Abbas, Suhad

	Synthesis and Bioactivity of new complexes containing multi-substituted aryl imidazole as ligands
Al-Zahraa Journal for Health and Medical Sciences
Volume 3, Issue 3, September 2025, Pages 140-161 PDF (2.27 M)
Document Type: Research Article
Authors
Howraa Khudair^* ¹; Sawsan Abbas²; Suhad Abbas¹
¹Department of Chemistry, College of Science, University of Kerbala, Karbala, Iraq
²department of Chemistryو Collage of pure science -University of Kerbala
Abstract
In this study. new series of complexes containing a multi-substituted arylimidazole ligand, 4-methoxy-2-(1H-phenanthro[9,10-d]imidazol-2-yl)phenol, were prepared. The imidazole ligand (L) was prepared through a condensation reaction between a diketone (9,10-phenathroquinone), an aromatic aldehyde ( 2-hydroxy-5-methoxybenzaldehyde ), and ammonium acetate, in the presence of glacial acetic acid as a catalyst and solvent . Metal complexes were then prepared by reacting this ligand with transition metal salts, including Fe(II), Co(II), Cu(II), and Ni(II), in appropriate solvent such as ethanol, under controlled temperature and stirring conditions to check the formation of stable complexes. The structures of the Imidazole ligands were determined by elemental analyses, IR, 1H-NMR and molar conductance measurements. It is observed that the synthesized complexes have tetragonal and octahedral geometrical structures. The imidazole ligand (L) and its derivations play important application for supramolecular assemblies due to they can also provide bidentate N-donor sites for chelating with metal ions to form bridge ligands. Antibacterial activity of the ligand and its metal complexes were tested against selected bacteria by disc diffusion method
Keywords
9; 10- phenathroquinone; imidazole ligand; complex; antibacterial activity

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