A Comparative Study on the Biotransformation of Selected Steroids and Steroid Drugs Using Different Aspergillus Species

AL ANI, RAGHDA MAHMOOD

doi:10.33899/rjs.2025.164298.1506

	A Comparative Study on the Biotransformation of Selected Steroids and Steroid Drugs Using Different Aspergillus Species
Rafidain Journal of Science
Articles in Press, Accepted Manuscript, Available Online from 27 October 2025
Document Type: Research Paper
DOI: 10.33899/rjs.2025.164298.1506
Author
RAGHDA MAHMOOD AL ANI^*
Master of Biochemistry, Sakarya University, Institute of Natural Science, Sakarya, Turkiye
Abstract
In nature, it can be said that there are many types of stimulants. including those being in bacteria, plants, fungi, and animals. It is a scientific fact that microbial transformation plays an important role in the biotransformation of steroids, enabling the production of stereoselective products. Our primary goal in this research is to explain and clarify the concept of microbial biotransformation and its importance in producing molecules with properties deemed useful in the pharmaceutical industry. We also aim to highlight the importance of biotransformation in generating novel metabolites. Furthermore, we will shed light on the traits and features of some Aspergillus fungi. We have demonstrated the biotransformation of some steroids such as DHAE and steroid drugs by some Aspergillus species such as Aspergillus albicans and Aspergillus niger. In order to clarify the results and how these fungi metabolize their substrates, we will use a previously conducted experiment and then compare the results of the experiment with the results of other previous experiments. In conclusion, we hope that this work will be of benefit to students and researchers in the field of biochemistry.
Keywords
Microbial transformation; Steroids; Beclomethasone dipropionate BDP; Aspergillus glaucus; Aspergillus niger

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