Measuring the level of some trace elements (Zinc, Iron, Lead, Cadmium and copper) in the serum of acute kidney injury patients in Nineveh Governorate

Mustafa , Anwar S. Majeed, Layla A.

	Measuring the level of some trace elements (Zinc, Iron, Lead, Cadmium and copper) in the serum of acute kidney injury patients in Nineveh Governorate
Al-Kunooze Scientific Journal
Volume 8, Issue 1, February 2022, Pages 213-228 PDF (470.89 K)
Document Type: Original Article
Author
Layla A. Mustafa , Anwar S. Majeed
Abstract
Background: Evaluation of the level of trace minerals in blood serum is one of the important things that can give us evidence of acute kidney injury, as the high concentrations of some trace minerals such as (Iron, lead, Cadmium, and Copper) and low concentrations of other minerals such as (zinc) in the blood serum are considered one of the Evidence of acute kidney injury, Objective: is to try to Prove that increasing the Concentrations of Some trace minerals can Cause nephrotoxicity and acute kidney failure, while their Presence in normal proportions in blood serum is beneficial to the human body as antioxidants or Cofactor. Methods and Material: This cross-sectional study was conducted in (Ibn Sina, Al-Salam, and Al-Jumhuri) Teaching Hospitals and the Central Blood Bank in Mosul, Iraq. Between the period (May 2022 - February 2023), where the study included 124 blood samples collected from men and women who suffer from acute Kidney injury and 108 blood samples collected from control groups, whose ages ranged from (≤35-≥56 years). The levels of Iron, Lead, Cadmium, Zinc, and Copper were determined in the blood serum of both acute kidney injury patients and the control group by atomic absorption spectroscopy technique. Results: The results indicated a significant increase in the level of (Iron, Lead, Cadmium and Copper) at (P ≤ 0.05) compared to the control group, while a significant decrease in the level of Zinc at the probability level (p≤0.05) compared to the control group. Conclusion: We conclude, through our study, that the decrease in the concentration of Zinc in acute kidney injury patients is matched by an increase in the concentration of Copper on the other hand, while an increase in the concentration of minerals (Iron, Lead and Cadmium) occurs in acute kidney injury patients as a result of the accumulation of these minerals in the kidney after reaching toxicity
Keywords
Acute Kidney Injury; Cadmium; Copper; Iron; Lead; Trace minerals Zinc

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