Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line

Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari, Faten

	Evaluation of Anti -Cancer Potential of luteolin 7 -o- glucoside extracted from Cuminum cyminum and Ocimum basilicum in colon Cancer Cell Line
Al-Kunooze Scientific Journal
Volume 9, Issue 1, June 2023, Pages 68-78 PDF (534.14 K)
Document Type: Original Article
Author
Faten Essam Hussain, Ula M. Noor AlMousawi , Hiba Abdul- Razaq, Falah Hasan Shari
Abstract
This study involved two plant species of different plant families, cumin (Cuminum cyminum) family Apiaceae and basil (Ocimum basilicum) family Lamiaceae of medical and economic importance. Aim: study luteolin o -7- glucoside in both species and evaluate its potential effect on colon cancer. Method: extraction by (70% ethanol) using (Soxhlet and reflux), high-performance liquid chromatography (HPLC) for detection of compound , and in vitro evaluation of the potential biological activity of crude plant extracts and luteolin O-7 glycoside with anticancer activity of Colon HCT Cell lines were tested using (MTT) assay. Results: of in vitro anticancer activity study conducted against colon cancer cell line showed moderate cytotoxicity of these plant extracts and luteolin 0 7 glucoside compounds against colon cancer. In which inhibition in viability of colon cancer cell by Cuminum cyminum (17.48% at concentration 250µg , 18.39 at concentration 500µg and 34 at 1000µg ) , Ocimum basilicum showed inhibition in the viability of cancer cell (17.66 at 250 µg , 26.8 500µg and 40.6 at 1000µg) While luteolin 0 - 7-glucoside stander showed decrease in the viability of cancer cell by (29.14 at 250 µg 11.11 500µg and 39 at 1000µg
Keywords
luteolin; colon cancer; cumin; basil

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