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Gender-Based Differences in Digoxin Induced Toxicity: A Comprehensive Evaluation of Biochemical Parameters and Gonadal Tissue Histopathology in Rats | ||
| Al-Kunooze Scientific Journal | ||
| Volume 9, Issue 1, June 2023, Pages 79-87 PDF (920.77 K) | ||
| Document Type: Original Article | ||
| Author | ||
| Kassim Fawzi Abdulkareem, Abbas A. Khudhair | ||
| Abstract | ||
| Introduction: Although for centuries digoxin was widely used for the treatment of variable heart problems and still used, it is important to evaluate its effects on reproductive organs. Aim: The present study is designed to compare the effects of this medication in male and female rats. Materials and Methods: The study included four groups as follows: 3 groups treated with different doses of digoxin solution for 90 days and the 4th group as control. Results: The results revealed significant changes in liver enzymes and urea levels in male rats. On the other hands, there were no significant differences in serum troponin and creatinine levels between male and female rats. Histopathological changes showed varying degrees of suppression of spermatogenesis and emptying epididymis tubules. At the same time, the ovaries revealed small non-active corpora lutea without graafian follicles compared to control groups. Conclusion: The study concluded that male rats appear to be affected more than female rats, and digoxin negatively affects biochemical markers and gonadal tissue in both genders. | ||
| Keywords | ||
| Digoxin; Gonadal Tissue; rats; heart problem | ||
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