Relationship between Lipid Profile and DNA Fragmentation Index with Abnormal Semen

Ridha Mhaibes And Sahib Yahya Al-Murshidi, Ghadeer

	Relationship between Lipid Profile and DNA Fragmentation Index with Abnormal Semen
Al-Kunooze Scientific Journal
Volume 11, Issue 3, July 2025, Pages 78-85 PDF (413.84 K)
Document Type: Original Article
Author
Ghadeer Ridha Mhaibes and Sahib Yahya Al-Murshidi
Abstract
Male infertility exists as a complex medical issue which depends on multiple physiological and biochemical factors particularly lipid metabolism and genetic integrity. The research evaluated how lipid profile characteristics relate to DNA fragmentation index (DFI) in Iraqi men who have either normal or abnormal semen test results. The study enrolled 90 male participants who included 46 men with normal semen characteristics between ages 20 to 45 and 44 men with abnormal semen parameters. Semen samples underwent analysis for standard parameters and lipid profile and DFI. The aberrant semen group displayed elevated triglyceride (TG) levels at 19.32±5.60 mg/dl which exceeded normal group levels at 14.50±4.62 mg/dl (P<0.01). The analysis revealed no significant variation between cholesterol (CHO) levels (P=0.410) but LDL levels of the aberrant semen group (6.38±4.12 mg/dl) significantly diverged from the normal group levels (9.03±3.43 mg/dl with P<0.01). The DNA fragmentation index (DFI) levels of the aberrant semen group exceeded those of the normal semen group by a significant margin (31.66±16.15% versus 13.54±9.49%, P<0.01). This indicates that men with poor semen quality typically present with sperm DNA damage. The research findings suggest that abnormal lipid metabolism together with increased DNA fragmentation plays a role in male infertility development particularly among men with abnormal semen analysis results.
Keywords
Semen quality; lipid profile; DNA fragmentation; and male infertility

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