Effect of Lead Acetate in Some Physiological & Genetic Parameters in White Male Rat Rattus rattus

	Effect of Lead Acetate in Some Physiological & Genetic Parameters in White Male Rat Rattus rattus
journal of kerbala university
Article 1, Volume 7, Issue 1, 2011, Pages 295-301 PDF (0 K)
Abstract
The study was carried out at the department of biology,college of education,university of Karbala. Twenty adult male of rats were divided into four equal groups (5/groups).The first group was investigate with 1 ml normal saline and served as a control group.the second group T1 were investigate orally with (8 mg/kg LA) for 70th day, while the third group T2 were investigate orally with(16mg/kg LA)for 70th.and fourth group T3 were investigate orally with (24mg/kg LA) for 70th. body weight was calculated before and after each experiments. The animals were killed after 24 hours from the last dose of treatment.The blood samples were collected.The levels of hormones were measured.testes,epididymis,prostate,seminal vesicles was removed, weighted,and effecting of lead in sperm count and percent of normality of sperm and effecting of mitotic index The result revealed that significant decrease (P<0.05) in animals weight and reproductive organs and some accessory glands and effect on levels of Luteinizing hormone and testosterone hormone and sperm count accompanied by an increase(P<0.05) in mitotic index and percent of abnormality of sperm.this study conclude that animal treated & lead acetate have is negative effect on the effectivity of reproductive system where the lead induce oxidative stress and production ROS contribute in hindrance impare the between antioxidant and oxidant

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