The relationship between nitric oxide and age with entamoeba histolytica

Abdulridha And Rasha A. Noori, Teebah T.

	The relationship between nitric oxide and age with entamoeba histolytica
Al-Kunooze Scientific Journal
Volume 11, Issue 4, October 2025, Pages 19-27 PDF (575.88 K)
Document Type: Original Article
Author
Teebah T. Abdulridha and Rasha A. Noori
Abstract
Amebiasis, caused by Entamoeba histolytica, is a significant global health issue, particularly in regions with poor sanitation. Nitric oxide, an adaptable signaling molecule, plays a complex role in this infection. While NO can contribute to tissue destruction and inflammation, it also exhibits protective properties by aiding in wound healing and inhibiting parasite proliferation. Thus, NO's impact on amebiasis involves a delicate balance of harmful and useful effects. This study aimed to determine the relationships between age, Entamoeba histolytica infection, and nitric oxide levels in infected patients. This case-control study, conducted in Al-Najaf, Iraq, from September 2024 to January 2025, investigated nitric oxide levels in 50 confirmed Entamoeba histolytica infection cases by examining serum samples collected from patients at multiple hospitals. Serum samples were obtained and stored at -80°C for nitric oxide analysis. The study indicated that E. histolytica infection was most frequent among individuals aged 21-40 years. Additionally, a notable rise in nitric oxide levels was observed in infected patients between 31 and 49 years old. In conclusion, this study suggests Infection was most common in 21-40 year olds, while NO levels were significantly elevated in infected individuals aged 31-49.
Keywords
Entamoeba histolytica; Nitric oxide; Age; serum

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