Diagnostic utility of Serum biochemical parameters in early detection of bladder cancer

AL-Kalabi , Mohsin K. AL-Murshdi, Dhouha M.

	Diagnostic utility of Serum biochemical parameters in early detection of bladder cancer
Al-Kunooze Scientific Journal
Volume 11, Issue 4, October 2025, Pages 63-76 PDF (704.04 K)
Document Type: Original Article
Author
Dhouha M. AL-Kalabi , Mohsin K. AL-Murshdi
Abstract
Bladder cancer ranks ninth in frequency worldwide and is the most prevalent cancer in the urinary tract. Significant risk factors include smoking, occupational exposures, and environmental exposures. Hematuria without discomfort is one of the common symptoms. Examine the following risk factors for bladder cancer: age, gender, occupation, BMI, smoking, and place of residence. The majority of patients (66.15%) were men between the ages of 50 and 60. Examine biochemical factors, including: blood urea, creatinine, AST, ALT, cholesterol, and triglycerides (TG). Thirty healthy people served as the study's control group, while 70 bladder cancer patients participated. Standard methods were used to measure the samples, and SPSS software was used for statistical analysis. Patients with bladder cancer had significantly higher levels of creatinine and urea than healthy controls (P<0.05).AST levels did not differ considerably, whereas ALT levels were significantly lower (P=0.016). While the patients' cholesterol levels were not statistically significant, their triglycerides were considerably higher (P=0.017). Changes in creatinine, urea, ALT, and triglycerides indicate metabolic and renal disturbances associated with bladder cancer. Risk factors include age, gender, smoking, and occupation, highlighting the importance of early detection.
Keywords
Bladder cancer; Biochemical parameters; Urea; Creatinine; cholesterol; Triglycerides; AST; ALT; Early detection

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