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Effect of Ursodeoxycholic Acid in lowering neonatal indirect hyperbilirubinemia | ||
| Iraqi Postgraduate Medical Journal | ||
| Volume 25, Issue 2, April 2026, Pages 219-224 PDF (3 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.52573/ipmj.2025.164374 | ||
| Author | ||
| Raza Hasan Husain* | ||
| sulamani teaching hospital | ||
| Abstract | ||
| Background: Neonatal hyperbilirubinemia is one of the most frequent conditions in newborns. Around 60% of term and nearly 80% of preterm infants show visible jaundice during the first postnatal week. Aim: This study evaluated whether adding ursodeoxycholic acid (UDCA) to conventional phototherapy accelerates the decline of indirect bilirubin in neonates. Methods: A randomized controlled trial was carried out in the Neonatal Care Unit at Sulaimani Pediatric Teaching Hospital between February 2014 and February 2015. Two hundred neonates with indirect hyperbilirubinemia were enrolled and randomly assigned to: - Group A (n=100): Oral UDCA 10 mg/kg/day in two divided doses plus phototherapy. - Group B (n=100): Phototherapy alone. Randomization used a computer-generated block sequence (block size 4). Allocation was concealed in sealed opaque envelopes. Outcome assessors were blinded. Results: In Group A, mean total bilirubin declined to 11.7 ± 1.5, 8.8 ± 1.1, and 7.6 ± 0.9 mg/dL at 12, 24, and 36 hours, respectively. In Group B, bilirubin fell more slowly: 14.6 ± 1.6, 13.2 ± 5.8, 10.2 ± 1.4, and 9.1 ± 0.8 mg/dL at 12, 24, 36, and 48 hours. The average phototherapy duration was 23.2 ± 5.6 hours in Group A versus 41.1 ± 7.2 hours in Group B. Conclusion: The addition of UDCA to phototherapy significantly hastened bilirubin reduction and shortened treatment duration by about one day compared with phototherapy alone. Keywords: Neonatal jaundice, Indirect hyperbilirubinemia, Phototherapy, Ursodeoxycholic acid. | ||
| Keywords | ||
| Neonatal jaundice; Indirect hyperbilirubinemia; Phototherapy; Ursodeoxycholic acid | ||
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