Synthesis and Characterization of Substituted benzimidazole Ligand and Its Transition Metals Complexes

Tariq, Farah; Salih, Saba Mumtaz; Hussein, Hyffaa Younus

doi:10.33899/rjs.2025.165912.1523

	Synthesis and Characterization of Substituted benzimidazole Ligand and Its Transition Metals Complexes
Rafidain Journal of Science
Articles in Press, Accepted Manuscript, Available Online from 21 December 2025
Document Type: Research Paper
DOI: 10.33899/rjs.2025.165912.1523
Authors
Farah Tariq¹; saba mumtaz salih²; hyffaa younus hussein^* ²
¹Dept. of Chem., College of Science, Mosul University
²department of chemistry college of science university of mosul
Abstract
The research describes the complete synthesis of 2-((sec-butylthio)methyl)-1H-benzo[d]imidazole which scientists confirmed through elemental analysis and FTIR and UV–Vis and NMR and magnetic susceptibility and molar conductivity tests. The ligand coordinated with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) to form stable tetrahedral and octahedral complexes, as confirmed by spectral and magnetic data. Antimicrobial assays demonstrated that metal complexation significantly enhanced biological activity, with Cu(II) complexes showing the strongest inhibition against Staphylococcus aureus. The research shows that sulfur-functionalized benzimidazole derivatives have the potential to become effective building blocks for creating innovative antimicrobial drugs.This study reports the successful synthesis of a new sulfur-substituted benzimidazole ligand and its coordination with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II). Spectroscopic, magnetic, and elemental analyses confirmed that the ligand acts as a neutral bidentate donor, forming stable tetrahedral and octahedral complexes. Antimicrobial evaluation revealed a marked enhancement in biological activity upon complexation, with Cu(II) complexes showing the strongest effect against Staphylococcus aureus. These findings highlight the potential of sulfur-functionalized benzimidazoles as scaffolds for antimicrobial development. Future studies, including MIC determination, cytotoxicity assays, and docking analysis, are recommended to further validate their therapeutic promise. Future investigations should integrate cytotoxicity assays and molecular docking studies to assess therapeutic selectivity, while in vivo validation could substantiate their potential as lead antimicrobial candidates.
Keywords
Benzimidazole; sulfur coordination; transition metal complexes; spectral characterization; antimicrobial activity

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