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Biochemical Assessment of the Hepatoprotective Role of β-Amino Butyric Acid in Carbon Tetrachloride–Induced Liver Injury in Male Sprague-Dawley Rats | ||
| Al-Zahraa Journal for Health and Medical Sciences | ||
| Volume 3, Issue 4, December 2025, Pages 11-22 PDF (859.41 K) | ||
| Document Type: Research Article | ||
| Author | ||
| Estabraq Satar AlAbdali* | ||
| University of Anbar, College of Education for Women, Department of Biology, Anbar, Iraq | ||
| Abstract | ||
| Abstract: Liver damage is a serious disease that has a close relationship with toxic compounds such as carbon tetrachloride (CCl₄). This study was conducted to determine the possible protective and therapeutic effect of beta amino butyric acid (BABA), a non-protein amino acid, on this damage in male rats. Thirty adult mice were randomly divided into six groups (the experiment lasted 30 days). The negative control group received only saline, the positive control group received CCl₄ (0.08 of body weight (, and the remaining four groups (A, B, C, and D) received CCl₄ for liver damage and were subsequently treated with increased doses (50, 100, 150, and 200 mg/kg) of BABA (both substances were injected into the peritoneum). After laboratory tests of biochemical indicators, including measurement of plasminogen-1 activator inhibitor (PAI-1) and Protein phosphatase (PP) in serum using (ELISA), the results showed a significant reduction (P≤0.01) in these biochemical markers (PAI-1 and PP) in the group injected with CCl₄ only, indicating liver dysfunction, compared to the negative control. In contrast, the groups injected with low doses of BABA (50 and 100 mg/kg) showed significant improvement in these markers, suggesting that these doses can reduce this damage and restore liver function, while larger doses (150 and 200 mg/kg) showed partial improvement. These findings open a wider scope for research into the use of BABA as a potential treatment for liver damage, suggesting it could be a promising treatment to reduce liver disease caused by toxic compounds by reducing inflammation, regulating blood clotting | ||
| Keywords | ||
| Liver damage; PP; Liver functions; PAI-1 | ||
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