Characterization and antifungal susceptibility of isolated Candida from Vulvovaginitis

doi:10.29350/qjps.2025.190624

	Characterization and antifungal susceptibility of isolated Candida from Vulvovaginitis
Al-Qadisiyah Journal of Pure Science
Volume 30, Issue 2, December 2025, Pages 104-117 PDF (550.18 K)
DOI: 10.29350/qjps.2025.190624
Abstract
This study is concerned with the identification and characterization of Candida species that are responsible for vaginal candidiasis (VCV), and you evaluate the fungi's susceptibility to antifungal drugs. Also, the study determined biofilm formation ability and coagulase production numbers for the Candidensis strain. The total number of adult women taking part was 98 in our study. Cultures were then grown on slanted CHROMagar plates, where the Candida species were identified. The biofilms' formation was evaluated using the microtiter assay, while the coagulase was also tested. The determination of antifungal susceptibility was achieved by performing the disk diffusion method. Three Candida species were detected: Candida albicans (82%) and Candida auris (4%). Meanwhile, the next frequently occurring yeasts are Candida glabrata (10%) and Candida krusei (7%). Candida albicans is the main culprit in most human microbial invasions. Other fungal species may also be involved in such processes. The Candida of every specimen showed the presence of globally formed biofilm and coagulase production. C. albicans was the most common species causing VVC, followed by C. glabrata and C. krusei. The Candida isolates showed various virulence properties, such as biofilm formation and coagulase production. The detected antifungal resistance illustrates the necessity of continued surveillance and correct treatment of VVC to prevent the dissemination of resistant Candida strains.
Keywords
Candida; Vulvovaginal candidiasis; non-albicans Candida; NAC; Biofilms; Antifungal susceptibility

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