- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
The Role of Matrix Metalloproteinases (MMP) and C-Reactive Protein (CRP) in Patients With Cardiovascular Diseases | ||
| Al-Qadisiyah Journal of Veterinary Medicine Sciences | ||
| Volume 24, Issue 2, December 2025, Pages 130-138 PDF (566.82 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.29079/qjvms.2025.161286.1094 | ||
| Authors | ||
| Ridhab Hasan* 1; Sundus Hamzah2 | ||
| 1Department of Chemistry. College of Education/ University of Al-Qadisiyah | ||
| 2Department of Chemistry. College of Education/ University of Al-Qadisiyah, | ||
| Abstract | ||
| cardiovascular diseases (CVDs), including myocardial infarction, ischemic heart disease, stroke, and hypertension, remain leading causes of mortality worldwide. These diseases are influenced by poor lifestyle, diet, physical inactivity, smoking, and genetic factors. This study evaluated the role of C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) as potential biomarkers for CVD diagnosis. A total of 100 serum samples (60 CVD patients, 40 healthy controls) were collected from hospitals in Baghdad and Al-Diwaniyah. Samples were analyzed using sandwich ELISA in triplicate. Statistical analysis included independent t-tests, Pearson’s correlation, and ROC analysis. CRP levels were significantly elevated in CVD patients (4.06 ± 2.23 mg/L) compared to controls (0.849 ± 0.68 mg/L) (p < 0.0001). MMP-9 levels were also significantly higher (p < 0.0001). ROC curve analysis showed strong diagnostic performance, with an area under the curve (AUC) of 0.961 for CRP and 0.925 for MMP-9. CRP had perfect sensitivity (100%) and higher accuracy in identifying CVD. A weak inverse correlation was observed between CRP and MMP-9 (r = –0.121, p > 0.05), indicating they may operate through different biological pathways. Both CRP and MMP-9 are significantly elevated in CVD patients and may serve as useful, complementary biomarkers. CRP demonstrated superior diagnostic accuracy. Further longitudinal and multi-marker studies are recommended. | ||
| Keywords | ||
| Matrix Metalloproteinases; C-reactive protein; cardiovascular diseases | ||
|
Statistics Article View: 69 PDF Download: 78 |
||