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Detection of Gastrointestinal Nematodes Resistance Against Ivermectin in Sheep | ||
| Al-Qadisiyah Journal of Veterinary Medicine Sciences | ||
| Volume 24, Issue 2, December 2025, Pages 157-163 PDF (492.7 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.29079/qjvms.2025.164167.1107 | ||
| Authors | ||
| Nada Khalil Ibrahim1; Sadam Dhahir Hasan2; Qaes Talb Al-Obaidi* 3 | ||
| 1Department of anesthesia, Medical Technical Institute, Northern Technical University, Mosul, Iraq. | ||
| 2Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||
| 3Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul-Iraq | ||
| Abstract | ||
| To date, Ivermectin is one of the advisable medications widely used in the therapy, domination effort of internal and external parasites in ruminants, but its efficacy and resistance developing during the last years remain questionable. The efficacy of Ivermectin and the resistance state of gastrointestinal; round worms in sheep farms was the goal of the current work survey. 300 fecal samples collected from male sheep (≥7 months) represented 6 sheep flocks (n=730) from different regions in Mosul city, Iraq. The efficacy of the Ivermectin in one farm with EPG ≥200 was evaluated using a fecal egg count reduction test on day zero (0) and day 14 post-treatment by subcutaneously injecting Tectin® (each 1 ml contains 10 mg Ivermectin) 0.2 mg/kg B.W. Moreover, the World Association of Advancement for Veterinary Parasitology (WAAVP) guidelines were referenced to detect the resistance. The overall prevalence of gastrointestinal nematodes was 47%, comprising Haemonchus spp. 6.66%, Ostertagia spp. 8.66%, Nematodirus spp. 14%, and Trichostrongylus spp. 17.66%. The efficacy of Ivermectin (71%) and the lower limit confidence interval (95%) was 46%, indicating AR to Ivermectin. As documented above, resistance of nematodes to anthelmintic classes, including Ivermectin, could potentially serve as a risk role in propagation, consequence, and maintaining parasitic burden to the productivity of ruminant farms, in addition to solidification set for hindering, monitoring and awareness of the sources of resistance being recommended. | ||
| Keywords | ||
| Ivermectin; Sheep; Nematodes; Resistance; Efficacy | ||
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