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Evaluation Study of Angiotensin Converting Enzyme 2 role in Infertility in SARS COV-2 Patients | ||
| The Medical Journal of Basrah University | ||
| Article 8, Volume 43, Issue 2, December 2025 | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2025.161906.1308 | ||
| Authors | ||
| Sheima Nadim Kadhim* 1; Nadheerah Falih Neamah1; Hadeel Salman Al Ali2 | ||
| 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Basrah, Iraq | ||
| 2Department of Physiology, Al-Zahraa College of Medicine, University of Basrah, Basrah, Iraq | ||
| Abstract | ||
| Angiotensin converting enzyme 2 receptor is an entry point for COVID-19 infections into body cells. The review's primary objective is to provide readers with an in-depth comprehension of the potential impact of COVID-19 on the reproductive systems of both sexes. We have demonstrated that SARS-CoV-2 can impact on the urogenital tract as well. This indicates that it should be carefully considered while treating infected males who are of reproductive age. Two crucial physical barriers in males are the blood-epididymis (BEB) and the blood-testis barrier (BTB). Studies revealed that various viruses remain able to intrude through these defenses and then malfunction the testicles, even though they play a major role in male reproductive function. Consequently, this brief overview emphasizes the function of ACE2 receptors. Additionally, due to the indirect cytopathic consequences of viral replication and dissemination in the testis, coronaviruses may have a negative impact on male fertility. Most existing data indicate that SARS-CoV-2 has no impact on female reproduction. Cytokines and inflammation associated with nervous system injury could be a secondary mechanism by which the virus influences sex hormone levels. Angiotensin converting enzyme 2 down-regulation may be the cause of menstrual issues among infected women with SARS-CoV-2, irregular hormone levels, medications, and stress. The parameters have not changed significantly in vitro fertilization or the quality of ovarian follicles between the prior to and post-COVID-19 immunization groups | ||
| Keywords | ||
| ACE2; COVID-19; reproductive system; SARS CoV-2 | ||
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