miR-5192 Downregulation in Pediatric Leukemia: A Subtype-Specific Analysis

Ahbail, Zahraa Talib; Khudhair, Anfal Mohammed; Ibrahim, Maysaa Nihad

doi:10.32894/kjms.2026.167312.1241

	miR-5192 Downregulation in Pediatric Leukemia: A Subtype-Specific Analysis
Kirkuk Journal of Medical Sciences
Volume 14, Issue 1, January 2026, Pages 16-24 PDF (962.1 K)
Document Type: Original research
DOI: 10.32894/kjms.2026.167312.1241
Authors
Zahraa Talib Ahbail^* ¹; Anfal Mohammed Khudhair¹; Maysaa Nihad Ibrahim²
¹Department of Microbiology, College of Medicine, University of AL-Iraqia, Baghdad, Iraq
²Department of Pediatrics, College of Medicine, University of AL-Iraqia, Baghdad, Iraq
Abstract
Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Depending on context, they may act as tumor suppressors or oncogenes and therefore represent potential biomarkers for early detection, classification, and prognosis of childhood leukemia. This study aimed to evaluate the expression of miR-5192 in pediatric leukemia. Methods: This case–control study included 50 children with leukemia and 50 apparently healthy controls aged 1–13 years. miR-5192 expression was quantified using real-time polymerase chain reaction (RT-qPCR). Results: miR-5192 expression was significantly lower in leukemic children than in controls (−1.91 ± 4.62414 vs. −0.10 ± 2.80491, respectively; p = 0.020). Differences in miR-5192 expression were also observed among leukemia subtypes. Conclusion: miR-5192 is downregulated in pediatric leukemia, supporting a potential tumor-suppressor role. Downregulation appeared consistent in acute myeloid leukemia (AML) and T-acute lymphoblastic leukemia (T-ALL), whereas its association with B-acute lymphoblastic leukemia (B-ALL) remains uncertain.
Keywords
Pediatric leukemia; MicroRNAs; miR-5192

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