AL-Dagestani, E., Hamza, M. (2026). Association of vitamin D status with ferritin and TSH levels across age and sex groups: a cross-sectional study. , 20(1), 85-91. doi: 10.37652/juaps.2025.162686.1518
Enaam Ahmed AL-Dagestani; Mohammad Hamza. "Association of vitamin D status with ferritin and TSH levels across age and sex groups: a cross-sectional study". , 20, 1, 2026, 85-91. doi: 10.37652/juaps.2025.162686.1518
AL-Dagestani, E., Hamza, M. (2026). 'Association of vitamin D status with ferritin and TSH levels across age and sex groups: a cross-sectional study', , 20(1), pp. 85-91. doi: 10.37652/juaps.2025.162686.1518
AL-Dagestani, E., Hamza, M. Association of vitamin D status with ferritin and TSH levels across age and sex groups: a cross-sectional study. , 2026; 20(1): 85-91. doi: 10.37652/juaps.2025.162686.1518
Association of vitamin D status with ferritin and TSH levels across age and sex groups: a cross-sectional study
1Department of Medical Physics, College of Science, University of Mosul, Iraq
2Department of Chemistry, College of Science, University of Zakho, Dohuk, Iraq
Abstract
Vitamin D deficiency has been implicated in disturbances of thyroid function and iron metabolism, but data from Iraqi clinical populations remain limited. We performed a hospital-based cross-sectional study (August 2024-January 2025) of 99 adults (15-45 years; 49 males, 50 females) attending Mosul General Hospital to examine associations between serum 25-hydroxyvitamin D status and two biochemical markers: thyroid-stimulating hormone (TSH) and ferritin. Participants were classified as vitamin D deficient (≤10 ng/mL, n = 37), insufficient (11-20 ng/mL, n = 31), or sufficient (>20 ng/mL, n = 31). Mean TSH was highest in the deficient group (5.09 ± 0.77 μIU/mL) and lowest in the sufficient group (1.90 ± 0.13 μIU/mL; p < 0.001). Mean ferritin was lowest in the deficient group (42.8 ± 3.07 ng/mL) and higher in the sufficient group (60.26 ± 7.3 ng/mL; p = 0.03). Correlation analysis showed a significant inverse association between vitamin D and TSH (r = -0.488, p < 0.001) and a positive association between vitamin D and ferritin (r = 0.212, p = 0.035). These findings indicate that lower vitamin D status is associated with higher TSH and lower iron stores in this hospital cohort. Consideration of vitamin D and iron status may aid the interpretation of abnormal TSH values and warrants prospective investigation to test whether nutritional correction modifies thyroid-related outcomes.