- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
New coordination insights into paracetamol and 1,10-phenanthroline metal complexes: Synthesis, characterization, DFT calculations, and antimicrobial study | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 20, Issue 1, April 2026, Pages 165-172 PDF (1.25 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2025.160616.1386 | ||
| Authors | ||
| Zaynab Alkhafagi1; Ali J. A. Al-Sarray* 2; Taghreed Al-Noor1; Omar Al-Obaidi3; Marei El-Ajaily4 | ||
| 1Department of Chemistry, Ibn -Al-Haithem College of Education for Pure Science, University of Baghdad, Baghdad, Iraq | ||
| 2Polymer Research Unit, College of Science, Mustansiriyah University, Baghdad, Iraq | ||
| 3Chemistry Department, College of Science, University of Anbar, Iraq | ||
| 4Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya | ||
| Abstract | ||
| Seven novel bidentate metal complexes of paracetamol (Para) and 1,10- Phenanthroline (Phen), with the general formula [M(Para)(Phen)2]Cl2 (M(II) = Mn, Fe, Co, Ni, Cu, Zn, and Cd), were synthesized in the present work and characterized by metal content, conductivity, melting point, elemental analysis, magnetic moment measurements, and UV-Vis and FT-IR spectroscopies. The molar conductance values further indicate that the complexes are electrolytic in nature. Paracetamol coordinates through its carbonyl (C=O) group and the amide nitrogen, whereas phenanthroline binds via its (N,N) donor atoms; therefore, both ligands act as bidentate, neutral donors. All complexes exhibit octahedral geometry, with one paracetamol and two phenanthroline ligands surrounding the metal ion. The antimicrobial activity was evaluated against two Gram-positive and two Gram-negative bacteria, as well as the fungus Candida albicans. DFT calculations were performed for selected complexes to obtain optimized structures and analyze electronic orbitals and related parameters. | ||
| Keywords | ||
| 1; 10-Phenanthroline; Antimicrobial activity; Coordination compounds; Metal complexes; Paracetamol | ||
|
Statistics Article View: 148 PDF Download: 237 |
||