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Moringa Oleifera L. Extract Modifies Oxidative Stress and Metabolic Changes Associated with Diabetes in Male Rats | ||
| Anbar Journal of Agricultural Sciences | ||
| Article 15, Volume 24, Issue 1, March 2026, Pages 136-145 PDF (639.38 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.32649/ajas.2026.191225 | ||
| Authors | ||
| H. H. Abd1; I. I. Waheeb2; A. A. Kareem3; H. I. A. Ahmed4 | ||
| 1Biological Sciences, College of Education, Al-Fallujah University, Iraq | ||
| 2Ministry of Education, General Director of Education, Anbar, Iraq | ||
| 3Department of Chemistry, College of Education for Pure Sciences, University of Kerbala | ||
| 4Biotechnology Research Center, Al-Nahrain University | ||
| Abstract | ||
| Diabetes is a metabolic illness marked by chronically high blood sugar levels caused by oxidative stress and free radicals, which leads to pancreatic beta cell malfunction and insulin resistance, worsening the condition. This study investigated the protective effect of moringa oleifera leaf extract (MLE) on some biochemical variables in diabetic male rats treated with alloxan, which increased blood sugar levels. Male rats weighing 180 ± 150 g on average were placed in four groups, each containing five male rats. Several major biochemical tests were conducted on glucose, HbA1c, lipid levels, renal function indices, and antioxidant levels. The results showed that MLE significantly reduced glucose and HbA1c levels, lipid profile, and kidney function while enhancing antioxidant activity and reducing oxidative stress in the diabetic rats. This could be due to the compounds in the MLE, such as flavonoids and phenolic acids, modifying enzyme catalytic activity and compensating for diabetes-induced defects in rats. As such, MLE can be regarded as a potent antioxidant, mitigating the effects of free radicals and metabolic abnormalities associated with diabetes | ||
| Keywords | ||
| Moringa oleifera leaf extract; Alloxan; Antioxidant activity; Free radicals; Biochemical parameters | ||
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