H., A., Khlybov, A. (2026). Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review. , 19(1), 1-10. doi: 10.30772/qjes.2025.163867.1690
Atheer S. H.; A. Khlybov. "Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review". , 19, 1, 2026, 1-10. doi: 10.30772/qjes.2025.163867.1690
H., A., Khlybov, A. (2026). 'Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review', , 19(1), pp. 1-10. doi: 10.30772/qjes.2025.163867.1690
H., A., Khlybov, A. Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review. , 2026; 19(1): 1-10. doi: 10.30772/qjes.2025.163867.1690

Strategies to enhance Biocompatibility via additive manufacturing for medical applications: A state-of-the-art review

Al-Qadisiyah Journal for Engineering Sciences
Article 1, Volume 19, Issue 1, March 2026, Pages 1-10    PDF (6.54 M)
Document Type: Review Paper
DOI: 10.30772/qjes.2025.163867.1690
Authors
Atheer S. H.; A. Khlybov*
Nizhny Novgorod State Technical University n.a. R.E. Alekseev, Nizhny Novgorod, Russia.
Abstract
In this review article, various cutting-edge strategies are addressed that aim to enhance the mechanical and functional properties of Biocompatibility metal, which are manufactured using additive manufacturing techniques, in particular for biomedical applications such as implants and prostheses. Additive manufacturing has several advantages, including time saving and cost reduction, especially in small product manufacturing processes and prototypes, freedom of design for complex shapes that are difficult to achieve by traditional methods, the advantage of reducing waste and material waste, the possibility of customizing products to order, enhancing sustainability and reducing environmental impact, and others. It can be said that most of the previous studies focused either on the biological properties of biometallics that were manufactured using addition techniques or improving mechanical properties, while comprehensive strategies that integrate the two aspects together have not been reviewed, and this article shows how to achieve synergistic improvements between the two performances. Any modern integrative revision combines various strategies (alloying, microscopic, surface, computational).
Keywords
Additive manufacturing; Biocompatibility; Stainless steel; Selective laser fusion SLM; Corrosion Resistance
References
  1.  H. H. Huang, L. J. Hargrove, M. Ortiz-Catalan, and J. W. Sensinger, “Integrating upper-limb prostheses with the human body: Technology advances,
    readiness, and roles in human–prosthesis interaction,” Annual Review of Biomedical Engineering, vol. 26, no. Volume 26, 2024, pp. 503–528, 2024. [Online].
    Available: https://doi.org/10.1146/annurev-bioeng-110222-095816
  2. M. H. Mobarak, M. A. Islam, N. Hossain, M. Z. Al Mahmud, M. T. Rayhan, N. J. Nishi, and M. A. Chowdhury, “Recent advances of
    additive manufacturing in implant fabrication – a review,” Applied Surface Science Advances, vol. 18, p. 100462, 2023. [Online]. Available:
    https://doi.org/10.1016/j.apsadv.2023.100462
  3. Y. Wu, J. Liu, L. Kang, J. Tian, X. Zhang, J. Hu, Y. Huang, F. Liu, H. Wang, and Z. Wu, “An overview of 3d printed metal implants in orthopedic applications:
    Present and future perspectives,” Heliyon, vol. 9, no. 7, p. e17718, 2023. [Online]. Available: https://doi.org/10.1016/j.heliyon.2023.e17718
  4. X. Tong, X. Hong, L. Chen, Y. Zhang, Y. Wang, Y. Chen, Y. Zhu, C. Wang, L. Zhu, J. Lin, S. Huang, J. Ma, and P. Luo, “Degradable zn–5ce alloys with high
    strength, suitable degradability, good cytocompatibility, and osteogenic differentiation fabricated via hot-rolling, hot-extrusion, and high-pressure torsion
    for potential load-bearing bone-implant application,” Journal of Materials Research and Technology, vol. 28, pp. 1752–1763, 2024. [Online]. Available:
    https://doi.org/10.1016/j.jmrt.2023.12.098
  5. A. Daniel, S. Anand, J. Naveen, T. Khan, and S. Khahro, “Advancement in biomedical implant materials—a mini review,” Frontiers in Bioengineering and
    Biotechnology, vol. 12, 2024. [Online]. Available: https://doi.org/10.3389/fbioe.2024.1400918
  6.  K. Mosas, A. Chandrasekar, A. Dasan, A. Pakseresht, and D. Galusek, “Recent advancements in materials and coatings for biomedical implants,” Gels, vol. 8,
    no. 5, 2022. [Online]. Available: https://doi.org/10.3390/gels8050323
  7. G. Tang, Z. Liu, Y. Liu, J. Yu, X. Wang, Z. Tan, and X. Ye, “Recent trends in the development of bone regenerative biomaterials,” Frontiers in Cell and
    Developmental Biology, vol. 9, p. 665813, 2021. [Online]. Available: https://doi.org/10.3389/fcell.2021.665813
  8. Y. Ahmed, N. K. Ankah, N. Ogunlakin, I. ulhaq Toor, and W. Farooq, “Exploring the future of metallic implants: a review of biodegradable and
    non-biodegradable solutions,” Corrosion Reviews, vol. 43, no. 5, pp. 495–521, 2025. [Online]. Available: https://doi.org/10.1515/corrrev-2024-0125
  9. C. Mocanu and C. Caltabellotta, “Biomaterials (metal/ceramic), advantages and disadvantages in medical prosthetics,” Medicine and materials, vol. 4, no. 3,
    pp. 141–148, 2024. [Online]. Available: https://doi.org/10.36868/MEDMATER.2024.04.03.141
  10. M.-S. Baltatu, D.-D. Burduhos-Nergis, D. P. Burduhos-Nergis, and P. Vizureanu, “Advanced metallic biomaterials,” Materials research forum llc, vol. 118,
    no. 1, p. 162, 2022. [Online]. Available: https://doi.org/10.21741/9781644901779
  11. M. Nikolova and M. Apostolova, “Advances in multifunctional bioactive coatings for metallic bone implants,” materials, vol. 16, no. 1, p. 183, 2023. [Online].
    Available: https://doi.org/10.3390/ma16010183
  12. H. D. Nguyen, A. Pramanik, A. Basak, Y. Dong, C. Prakash, S. Debnath, S. Shankar, I. Jawahir, S. Dixit, and D. Buddhi, “A critical review on additive
    manufacturing of ti-6al-4v alloy: microstructure and mechanical properties,” Journal of Materials Research and Technology, vol. 18, pp. 4641–4661, 2022.
    [Online]. Available: https://doi.org/10.1016/j.jmrt.2022.04.055
  13. H. Zhang, B. Feng, D. Lin, W. Guo, Y. Cai, J. Xue, J. Aslam, Q. Song, B. Wang, and Z. Liu, “Enhanced mechanical properties of ti-6al-4v titanium alloy
    through laser-assisted burnishing,” The International Journal of Advanced Manufacturing Technology, vol. 135, no. 5, pp. 2635–2648, 2024. [Online].
    Available: https://doi.org/10.21203/rs.3.rs-4773365/v1
  14. G. Mani, D. Porter, S. Collins, T. Schatz, A. Ornberg, and R. Shulfer, “A review on manufacturing processes of cobalt-chromium alloy implants and their
    impact on corrosion resistance and biocompatibility,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 112, no. 6, p. e35431,
    2024. [Online]. Available: https://doi.org/10.1002/jbm.b.35431
  15. D. Smith, P. Pickett, T. Grabowski, J. Thorpe, and F. Azarmi, “Mechanical properties of cobalt chromium alloy manufactured by direct energy deposition
    technology,” Journal of Thermal Spray Technology, vol. 34, no. 2, pp. 674–689, 2025. [Online]. Available: https://doi.org/10.1007/s11666-024-01913-1
  16. H. Al-Safi, S. M., L. E. A. Al-Jorani, A. K. J, and K. al azzawi, “Effect of adding chrome-cobalt, titanium, and tungsten alloys to cold-cure acrylic resin oral
    stent for cancer patients with head and neck radiotherapy,” Journal of Emergency Medicine, trauma and acute care, vol. 2024, no. 2, p. 11, 2024. [Online].
    Available: https://doi.org/10.5339/jemtac.2024.uncidc.11
  17. T. C. Dzogbewu and D. D. Beer, “powder bed fusion of multimaterials,” Journal of Manufacturing and Materials Processing, vol. 7, no. 1, p. 15, 2023.
    [Online]. Available: https://doi.org/10.3390/jmmp7010015
  18. M. H. Sehhat and A. Mahdianikhotbesara, “powder spreading in laser-powder bed fusion process,” granular matter, vol. 23, no. 89, 2021. [Online]. Available:
    https://doi.org/10.1007/s10035-021-01162-x
  19. R. Bidulsky, P. Petrousek, J. Bidulska, R. Hudak, J. zivcak, and M. Actis Grande, “Porosity quantification of additive manufactured ti6al4v
    and cocrw alloys produced by l-pbf,” Archives of Metallurgy and Materials, vol. vol. 67, no. No 1, pp. 83–89, 2022. [Online]. Available:
    https://doi.org/10.24425/amm.2022.137475
  20. P. Petrousek, T. Kvackaj, J. Bidulska, R. Bidulsky, M. A. Grande, D. Manfredi, K.-P. Weiss, R. Kocisko, M. Luptak, and I. Pokorny, “Investigation of the
    properties of 316l stainless steel after am and heat treatment,” Materials, vol. 16, no. 11, 2023. [Online]. Available: https://doi.org/10.3390/ma16113935
  21. G. O. Barrionuevo, M. Walczak, P. Mendez, I. La F ´e-Perdomo, E. Chiluisa-Palomo, W. Navas-Pinto, and D. E. Cree, “Effect of porosity on tribological
    properties of medical-grade 316l stainless steel manufactured by laser-based powder bed fusion,” Materials, vol. 18, no. 3, 2025. [Online]. Available:
    https://doi.org/10.3390/ma18030568
  22. Y. K. Erdogan and B. Erkan, “Anodized nanostructured 316l stainless steel enhances osteoblast functions and exhibits anti-fouling properties,” ACS
    Biomaterials Science and Engineering, vol. 9, no. 2, pp. 693–704, 2023. [Online]. Available: https://doi.org/10.1021/acsbiomaterials.2c01072
  23. V. Madhavadas, D. Srivastava, U. Chadha, S. Aravind Raj, M. T. H. Sultan, F. S. Shahar, and A. U. M. Shah, “A review on metal additive manufacturing
    for intricately shaped aerospace components,” CIRP Journal of Manufacturing Science and Technology, vol. 39, pp. 18–36, 2022. [Online]. Available:
    https://doi.org/10.1016/j.cirpj.2022.07.005
  24. B. Blakey-Milner, P. Gradl, G. Snedden, M. Brooks, J. Pitot, E. Lopez, M. Leary, F. Berto, and A. du Plessis, “Metal additive manufacturing in aerospace: A
    review,” Materials Design, vol. 209, p. 110008, 2021. [Online]. Available: https://doi.org/10.1016/j.matdes.2021.110008
  25. C. Zhao, B. Shi, S. Chen, D. Du, T. Sun, B. J. Simonds, K. Fezzaa, and A. D. Rollett, “Laser melting modes in metal powder bed fusion additive
    manufacturing,” Rev. Mod. Phys., vol. 94, p. 045002, Oct 2022. [Online]. Available: https://doi.org/10.1103/RevModPhys.94.045002
  26. J. Cui, H. Liang, S. Chen, Y. Shao, H. Chen, and et al., “Recent progress and perspectives in laser additive manufacturing of biodegradable zinc alloy,”
    Journal of Materials Research and Technology, vol. 33, pp. 6958–6979, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2024.11.012
  27. K. Tesaˇr, J. Lu ˇn ´a ˇckov ´a, M. Jex, M. ˇZaloudkov ´a, R. Vrbov ´a, M. Barto ˇs, P. Klein, L. Vi ˇstejnov ´a, J. Du ˇskov ´a, E. Filov ´a, Z. Sucharda, M. Steinerov ´a, S. Habr,
    K. Bal´ık, and A. Singh, “In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, zn alloying and polymer
    coating,” Journal of Magnesium and Alloys, vol. 12, no. 6, pp. 2472–2488, 2024. [Online]. Available: https://doi.org/10.1016/j.jma.2024.06.003
  28. A. Boukalov ´a, J. Kub ´asek, D. Ne ˇcas, P. Min ´arik, ˇCrtomir Donik, D. Dvorsk ´y, D. Vojt ˇech, A. Michalcov ´a, M. Godec, and I. Paulin, “Harmonizing
    microstructures and enhancing mechanical resilience: Novel powder metallurgy approach for zn–mg alloys,” Journal of Materials Research and Technology,
    vol. 31, pp. 2807–2819, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2024.06.223
  29. M.-M. Germaini, S. Belhabib, S. Guessasma, R. Deterre, P. Corre, and P. Weiss, “Additive manufacturing of biomaterials for bone tissue engineering– a critical review of the state of the art and new concepts,” Progress in Materials Science, vol. 130, p. 100963, 2022. [Online]. Available:
    https://doi.org/10.1016/j.pmatsci.2022.100963
  30. Y. Chen, J. Lock, and H. H. Liu, “Chapter 9 - nanocomposites for cartilage regeneration,” Woodhead Publishing Series in Biomaterials, pp. 213–260, 2023.
    [Online]. Available: https://doi.org/10.1016/B978-0-12-818627-5.00018-X
  31. A. Pandya, P. Upadhaya, S. Lohakare, T. Srivastava, S. Mhatre, S. Pulakkat, and V. B. Patravale, “Chapter 6 - nanobiomaterials for regenerative medicine,”
    Nanotechnology in Medicine and Biology, pp. 141–187, 2022. [Online]. Available: https://doi.org/10.1016/B978-0-12-819469-0.00007-1
  32. R. Jairo and A. Gonzalez-Lizardo, “Plasma-treated polymeric biomaterials for improved surface and cell adhesion,” arxiv preprint arxiv, no. 6, p. 03883,
    2025. [Online]. Available: https://doi.org/10.48550/arXiv.2504.03883
  33. J. Mayers, B. Hofman, I. Sobiech, and M. Kwesiga, “Insights into the biocompatibility of biodegradable metallic molybdenum for cardiovascular applications-a
    critical review,” Frontiers in Bioengineering and Biotechnology, vol. 12, p. 1457553, 2024. [Online]. Available: https://doi.org/10.3389/fbioe.2024.1457553
  34. J. K. Balangao, “Corrosion of metals: factors, types and prevention strategies,” Journal of Chemical Health Risks, vol. 14, no. 1, pp. 79–87, 2024. [Online].
    Available: https://jchr.org/index.php/JCHR/article/view/2120
  35. E. L. Medina, J. Vaca-Gonz ´alez, W. Aperador, S. Ramtani, C. Falentin-Daudre, and D. Garz ´on-Alvarado, “Review of advanced coatings for metallic
    implants: a study/proposal on yttria-stabilized zirconia and silver-doped hydroxyapatite,” JOM, vol. 77, p. 5345–5361, 2025. [Online]. Available:
    https://doi.org/10.1007/s11837-025-07345-8
  36. Y. Xu, Y. Li, T. Chen, C. Dong, and X. B. K. Zhang, “A short review of medical-grade stainless steel: corrosion resistance and novel techniques,” Journal of
    Materials Research and Technology, vol. 29, pp. 2788–2798, 2024. [Online]. Available: https://doi.org/10.1016/j.jmrt.2024.01.240
  37. F. Mart´ınez-P ´erez, “Corrosi ´on. tipos. prevenci ´on,” Revista Ciencias T ´ecnicas Agropecuarias, vol. 32, no. 2, jun. 2023. [Online]. Available:
    https://cu-id.com/2177/v32n2e10
  38. M. Yi, W. Tang, Y. Zhu, C. Liang, Z. Tang, Y. Yin, W. He, S. Sun, and S. Su, “A holistic review on fatigue properties of additively manufactured metals,”
    Journal of Materials Processing Technology, vol. 329, p. 118425, 2024. [Online]. Available: https://doi.org/10.1016/j.jmatprotec.2024.118425
  39. L. Zhou, J. Miller, J. Vezza, M. Mayster, M. Raffay, Q. Justice, Z. A. Tamimi, G. Hansotte, L. D. Sunkara, and J. Bernat, “Additive manufacturing: a
    comprehensive review,” Sensors, vol. 24, no. 9, p. 2668, 2024. [Online]. Available: https://doi.org/10.3390/s24092668
  40. A. I. Saimon, E. Yangue, X. Yue, Z. J. Kong, and C. Liu, “Advancing additive manufacturing through deep learning: A comprehensive review of current
    progress and future challenges,” IISE Transactions, vol. 58, no. 1, pp. 33–56, 2026. [Online]. Available: https://doi.org/10.1080/24725854.2024.2443592
  41. K. Janus, A. Jarzebska, A. Wojcik, A. Garbacz-Klempka, J. Piekło, S. Terlicka, M. Piekos, J. J. Sobczak, O. Krasa, and L. Krawczyk, “microstructure and
    mechanical properties of scalmalloy produced by selective laser melting in terms of long-term applications,” Archives of Civil and Mechanical Engineering,
    vol. 25, no. 4, p. 183, 2025. [Online]. Available: https://doi.org/10.1007/s43452-025-01242-2
  42. Z. Fathipour, M. Hadi, O. Bayatb, and F. Fernandesc, “Improvement of surface properties and wear resistance of selective laser melting-fabricated inconel
    625 alloy by ultrasonic nanocrystal surface modification for demanding applications,” Tribology transactions, vol. 68, no. 2, pp. 249–263, 2025. [Online].
    Available: https://doi.org/10.1080/10402004.2025.2457970
  43. C. Bulut, F. Yıldız, T. Varol, G. Kaya, and T. O. Erg ¨uder, “Effects of selective laser melting process parameters on structural, mechanical, tribological, and
    corrosion properties of cocrfemnni high entropy alloy,” Metals and Materials International, vol. 30, no. 1, pp. 2982–3004, 2024. [Online]. Available:
    https://doi.org/10.1007/s12540-024-01694-w
  44. Y. Zhang, Y. Li, M. Song, Y. Li, S. Gong, and B. Zhang, “Tial alloy fabricated using electron beam selective melting: process, microstructure, and tensile
    performance,” Metals, vol. 14, no. 4, p. 482, 2024. [Online]. Available: https://doi.org/10.3390/met14040482
  45. M.-H. T. Chen, Yi-Cheng and S.-F. Ou, “optimized laser surface remelting of 3d-printed ti6al4v manufactured through electron beam melting,” JOM, vol. 77,
    no. 2, pp. 481–493, 2025. [Online]. Available: https://doi.org/10.1007/s11837-024-06870-2
  46. H. Hafizoglu, F. Memu, B. A. Hamat, H. E. Konokman, and N. Durlu, “Dynamic deformation behavior of the electron beam melted ti-6al-4v alloy,” Arabian
    Journal for Science and Engineering, vol. 50, no. 4, pp. 2541–2555, 2025. [Online]. Available: https://doi.org/10.1007/s13369-024-09166-4
  47. J. A. Lee, J. Park, M. J. Sagong, S. Y. Ahn, J.-W. Cho, S. Lee, and H. S. Kim, “Active learning framework to optimize process parameters
    for additive-manufactured ti-6al-4v with high strength and ductility,” Nature communications, vol. 16, no. 1, p. 931, 2025. [Online]. Available:
    https://doi.org/10.1038/s41467-025-56267-1
  48. S. Gain and D. Veeman, “A review on advances and challenges in wire arc additive manufacturing: process parameters, microstructural
    evolution and material performance across alloys,” Journal of alloys and compounds, vol. 1029, no. 1, p. 180735, 2025. [Online]. Available:
    https://doi.org/10.1016/j.jallcom.2025.180735
  49. Y. Gao, W. Jiang, D. Zeng, X. Liang, C. Ma, and W. Xiao, “Additive manufacturing of titanium alloys for biomedical applications: A systematic review,”
    Review of Materials Research, vol. 1, no. 1, p. 100011, 2025. [Online]. Available: https://doi.org/10.1016/j.revmat.2025.100011
  50. V. Goyal, G. Verma, and U. S. Dixit, “In-vitro study of ti6al4v alloy fabricated by laser-based additive manufacturing for orthopedic implant applications,” J
    Process Mechanical Engineering, 2024. [Online]. Available: https://doi.org/10.1177/09544089241289723
  51. B. Jin, Q. Wang, L. Zhao, A. Pan, X. Ding, W. Gao, Y. Song, and X. Zhang, “A review of additive manufacturing techniques and post-processing for
    high-temperature titanium alloys,” Metals, vol. 13, no. 8, p. 1327, 2023. [Online]. Available: https://doi.org/10.3390/met13081327
  52. Q. Wu, C. Qiao, Y. Wu, Z. Liu, X. Li, J. Wang, X. An, A. Huang, and C. V. S. Lim, “Numerical investigation on the reuse of recycled powders in powder bed
    fusion additive manufacturing,” Additive Manufacturing, vol. 77, p. 103821, 2023. [Online]. Available: https://doi.org/10.1016/j.addma.2023.103821
  53. N. Zakerin, K. Morshed-Behbahani, D. P. Bishop, and A. Nasiri, “Review of tribological and wear behavior of alloys fabricated via directed
    energy deposition additive manufacturing,” Journal of Manufacturing and Materials Processing, vol. 9, no. 6, p. 194, 2025. [Online]. Available:
    https://doi.org/10.3390/jmmp9060194
  54. Z. Liu, Q. Zhou, X. Liang, X. Wang, G. Li, K. Vanmeensel, and J. Xie, “Alloy design for laser powder bed fusion additive manufacturing: a critical review,”
    International Journal of Extreme Manufacturing, vol. 6, no. 2, p. 022002, jan 2024. [Online]. Available: https://doi.org/10.1088/2631-7990/ad1657
  55. I. Ara, D. Bajwa, and A. Raeisi, “A review on the wear performance of additively manufactured 316l stainless steel: process, structure, and performance,”
    Journal of materials science, vol. 60, p. 5686–5720, 2025. [Online]. Available: https://doi.org/10.1007/s10853-025-10775-z
  56. P. S. Humnabad, R. Tarun, and I. Das, “An overview of direct metal laser sintering (dmls) technology for metal 3d printing,” Journal of Mines, Metals and
    Fuels, vol. 70, no. 3A, pp. 127–133, 2022. [Online]. Available: https://doi.org/10.18311/jmmf/2022/30681
  57. K. Wang, J. Yin, X. Chen, L. Wang, H. Xiao, X. Liu, and Z. Huang, “Advances on direct selective laser printing of ceramics: An overview,” Journal of Alloys
    and Compounds, vol. 975, p. 172821, 2024. [Online]. Available: https://doi.org/10.1016/j.jallcom.2023.172821
  58. D. J. Liu, Yulin and F. Ning, “Sintering mechanisms in metal extrusion-based sintering-assisted additive manufacturing: State-of-the-art and perspectives,”
    Journal of Manufacturing Science and Engineering, vol. 147, no. 7, p. 070801, 2025. [Online]. Available: https://doi.org/10.1115/1.4068066
  59. M.-A. Pastre, Y. Quinsat, and C. Lartigue, “Effects of additive manufacturing processes on part defects and properties: a classification review,” International
    Journal on Interactive Design and Manufacturing, vol. 16, no. 4, pp. 1471–1496, 2022. [Online]. Available: https://doi.org/10.1007/s12008-022-00839-8
  60. L. Afroz, M. Qian, J. F. Y. Li, M. Easton, and R. Das, “Fatigue life of laser powder bed fusion (l-Pbf) alsi10mg alloy: effects of surface roughness and
    porosity,” Progress in additive manufacturing, vol. 10, no. 4, pp. 2423–2441, 2023. [Online]. Available: https://doi.org/10.2139/ssrn.4548909
  61. S. Pourrahimi and L. A. Hof, “On the post-processing of complex additive manufactured metallic parts: a review,” Advanced engineering materials, vol. 26,
    no. 10, p. 2301511, 2024. [Online]. Available: https://doi.org/10.1002/adem.202301511
  62. W. Huang, H. Garmestani, and S. Liang, “Microstructure evolution and the influence on residual stress in metal additive manufacturing with analytics,”
    Crystals, vol. 15, no. 5, p. 435, 2025. [Online]. Available: https://doi.org/10.3390/cryst15050435
  63. S. G. Irizalp, N. Saklakoglu, C. Apaydin, and K. Ayan, “Effects of porosity and microstructure on the fatigue fracture properties of ti6al4v alloy produced
    through selective laser melting,” The International Journal of Advanced Manufacturing Technology, vol. 138, no. 5, pp. 2573–2589, 2025. [Online]. Available:
    https://doi.org/10.1007/s00170-025-15630-8
  64. G. ´Alvarez, Z. Harris, K. Wada, C. Rodr´ıguez, and E. Mart´ınez-Pa ˜neda, “Hydrogen embrittlement susceptibility of additively manufactured 316l stainless
    steel: Influence of post-processing, printing direction, temperature, and pre-straining,” Additive Manufacturing, vol. 78, p. 103834, 2023. [Online]. Available:
    https://doi.org/10.1016/j.addma.2023.103834
  65. T. Dusautoir, B. Berthel, S. Fouvry, P. Matzen, and D. Meck, “Influence of post-processing treatments on fatigue limit of notched additive
    manufactured ti-6al-4v determined by rapid thermographic methodology,” International journal of fatigue, vol. 179, p. 108034, 2024. [Online]. Available:
    https://doi.org/10.1016/j.ijfatigue.2023.108034
  66. A. M. Mancisidor, M. B. Garc´ıa-Blanco, I. Quintana, P. J. Arrazola, E. Espinosa, M. Cuesta, J. Albizuri, and F. Garciandia, “Effect of post-processing
    treatment on fatigue performance of ti6al4v alloy manufactured by laser powder bed fusion,” Journal of Manufacturing and Materials Processing, vol. 7,
    no. 4, p. 119, 2023. [Online]. Available: https://doi.org/10.3390/jmmp7040119
  67. A. Mostafaei, R. Ghiaasiaan, I.-T. Ho, S. Strayer, K.-C. Chang, N. Shamsaei, S. Shao, S. Paul, A.-C. Yeh, S. Tin, and A. C. To, “Additive manufacturing of
    nickel-based superalloys: A state-of-the-art review on process-structure-defect-property relationship,” Progress in Materials Science, vol. 136, p. 101108,
    2023. [Online]. Available: https://doi.org/10.1016/j.pmatsci.2023.101108
  68. J. Chen and B. Chen, “Progress in additive manufacturing of magnesium alloys: a review,” materials, vol. 17, no. 15, p. 3851, 2024. [Online]. Available:
    https://doi.org/10.3390/ma17153851
  69. D. Tourret, R. Tavakoli, A. Boccardo, A. Boukellal, M. Li, and J. Molina-Aldareguia, “Emergence of rapid solidification microstructure in additive
    manufacturing of a magnesium alloy,” Modelling and Simulation in Materials Science and Engineering, vol. 32, p. 055012, 2024. [Online]. Available:
    https://doi.org/10.48550/arXiv.2404.16031
  70. U. L. Lee, S. Yun, H. Lee, H. L. Cao, S. H. Woo, Y. H. Jeong, T. G. Jung, C. M. Kim, and P. H. Choung, “Osseointegration of 3d-printed titanium implants with
    surface and structure modifications,” Dental Materials, vol. 38, no. 10, pp. 1648–1660, 2022. [Online]. Available: https://doi.org/10.1016/j.dental.2022.08.003
  71. C. Y. Lee, P. C. Kung, C. C. Huang, S. J. Shih, E. W. Huang, S. Y. Chen, M. H. Wu, and N. T. Tsou, “In vivo study of bone growth around additively
    manufactured implants with ti-6al-4v and bioactive glass powder composites,” J Orthop Res, vol. 43, no. 10, pp. 1796–1804, 2025. [Online]. Available:
    https://doi.org/10.1002/jor.70037
  72. D. Tourret, R. Tavakoli, D. Boccardo, K. Boukellal, M. Li, and J. Molina-Aldareguia, “Emergence of rapid solidification microstructure in additive
    manufacturing of a magnesium alloy,” Modelling and simulation in materials science and engineering, vol. 32, no. 5, p. 055012, 2024. [Online]. Available:
    https://doi.org/10.48550/arXiv.2404.16031
  73. K. K. Thomas, M. N. Zafar, W. G. Pitt, and G. A. Husseini, “Biodegradable magnesium alloys for biomedical implants: properties, challenges,
    and surface modifications with a focus on orthopedic fixation repair,” Applied sciences, vol. 14, no. 1, p. 10, 2023. [Online]. Available:
    https://doi.org/10.3390/app14010010
  74. J. Liu, B. Liu, S. Min, B. Yin, B. Peng, Z. Yu, C. Wang, X. Ma, P. Wen, Y. Tian, and Y. Zheng, “Biodegradable magnesium alloy we43 porous scaffolds
    fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation,” Bioactive Materials, vol. 16, pp.
    301–319, 2022. [Online]. Available: https://doi.org/10.1016/j.bioactmat.2022.02.020
  75. K. Xie, N. Wang, Y. Guo, S. Zhao, J. Tan, L. Wang, G. Li, J. Wu, Y. Yang, W. Xu, J. Chen, W. Jiang, P. Fu, and Y. Hao, “Additively manufactured
    biodegradable porous magnesium implants for elimination of implant-related infections: An in vitro and in vivo study,” Bioactive Materials, vol. 8, pp.
    140–152, 2022. [Online]. Available: https://doi.org/10.1016/j.bioactmat.2021.06.032
  76. S. Pattanayak, P. Dash, S. Satpathi, A. K. Sahoo, N. R. Das, B. Nayak, and S. K. Sahoo, “Additive manufacturing of 316l stainless steel orthopedic implant
    with improved in vitro hemocompatibility and hydrophilicity for osteoinduction in wistar rat model,” Biomaterials Advances, vol. 175, p. 214322, 2025.
    [Online]. Available: https://doi.org/10.1016/j.bioadv.2025.214322
  77. S. Prakrathi, V. M. Dayasagar, G. D., Yashavantha, and Y. Singh, “A study on metal 3d printing of 316l stainless steel for biomedical
    implants,” International conference on additive manufacturing. Singapore: Springer Nature Singapore, vol. 1, pp. 1–7, 2024. [Online]. Available:
    https://doi.org/10.1007/978-981-97-6016-9 1
  78. Y. K. Erdogan and B. Ercan, “Anodized nanostructured 316l stainless steel enhances osteoblast functions and exhibits anti-fouling properties,” ACS
    Biomaterials Science and Engineering, vol. 9, no. 2, pp. 693–704, 2023. [Online]. Available: https://doi.org/10.1021/acsbiomaterials.2c01072
  79. Z. Wang, Y. Yuan, S.Zhang, Y. Lin, and J.Tan, “A multi-state fusion informer integrating transfer learning for metal tube bending early wrinkling prediction,”
    applied soft computing, vol. 151, p. 110991, 2024. [Online]. Available: https://doi.org/10.1016/j.asoc.2023.110991
  80. H. Huang, P. Zhang, M. Tang, L. Shen, Z. Yu, H. Shi, and Y. Tian, “Biocompatibility of micro/nano structures on the surface of ti6al4v and ti-based bulk metallic
    glasses induced by femtosecond laser,” Biomaterials Advances, vol. 139, p. 212998, 2022. [Online]. Available: https://doi.org/10.1016/j.bioadv.2022.212998
  81. H. Zhang, Z. Wu, Z. Wang, X. Yan, X. Duan, and H. Sun, “Advanced surface modification techniques for titanium implants: A review of
    osteogenic and antibacterial strategies,” Frontiers in Bioengineering and Biotechnology, vol. 13, no. 1, p. 1549439, 2025. [Online]. Available:
    https://doi.org/10.3389/fbioe.2025.1549439
  82. S. E. Baakili, P. Munyensanga, M. Bricha, and K. E. Mabrouk, “Porous metallic implants from additive manufacturing to biocorrosion: A review,” Johnson
    Matthey Technology Review, vol. 68, no. 1, pp. 71–90, 2024. [Online]. Available: https://doi.org/10.1595/205651324X16826780236175
  83. A. Padsalgikar, “Applications of polyurethanes in medical devices,” vol. ISBN: 9780128196731, no. 1st Edition, 2022.
  84. Q. Zhong, X. Pan, Y. Chen, Q. Lian, J. Gao, Y. Xu, J. Wang, Z. Shi, and H. Cheng, “prosthetic metals: release, metabolism and toxicity,” international journal
    of nanomedicine, vol. 5, no. 19, pp. 5245–5267, 2024. [Online]. Available: https://doi.org/10.2147/ijn.s459255
  85. L. Leila and M. Palmieri, “Review of the use of metals in biomedical applications: biocompatibility, additive manufacturing technologies, and standards and
    regulations,” metals, vol. 14, no. 9, p. 1039, 2024. [Online]. Available: https://doi.org/10.3390/met14091039
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