Metformin-dose-dependent effect on both pituitary hormones and vitamin D levels in women with PCOS in Kerbala

ALhussain, Nada ABD

	Metformin-dose-dependent effect on both pituitary hormones and vitamin D levels in women with PCOS in Kerbala
Al-Zahraa Journal for Health and Medical Sciences
Volume 4, Issue 1, March 2026, Pages 335-346 PDF (545.4 K)
Document Type: Research Article
Author
nada ABD ALhussain^*
Department of Food Science, College of agriculture, university of kerbala, Iraq.
Abstract
The relevance of research is to determine the impact of metformin dosages on vitamin D, estrogen, PRL, LH and FSH concentrations in women with PCOS in Kerbala. In this research, eighty females between ages 20 and 40 were used. Between February 2, 2025, and August 15, 2025, women came to the Indian General Hospital in Kerbala. Subjects were grouped into four different groups. G1: Group of 20 females diagnosed with Polycystic Ovaries who were given 250 mg metformin three times daily for four months. G2: Group of 20 females with PCOS who were given metformin dose of 500 mg three times daily for four months.G3: Group of 20 females diagnosed with PCOS were given 800mg metformin three times daily for four months. G4: Group of 20 females with PCOS were prescribed to take a metformin dosage of 1000 mg thrice daily for four months. Serum testing was conducted five months post-administration of the drugs using ELISA test for FSH, LH, PRL, Estrogen, and vitamin D levels. show that metformin at G4 with a dose of 1000 mg three times daily for 4 months has a significant effect on vitamin D ,estrogen, PRL, LH and FSH concentrations.
Keywords
Polycystic Ovary Syndrome; Metformin; Vitamin D; Pituitary hormones

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