The Protective Role of <em>Arthrospira platensis</em> Nanoparticles in Induced Testicular Damage in Male Rats

Jasimh, Adnan M; Abukhomra, Ahmed Samir

doi:10.29079/qjvms.2025.167182.1154

	The Protective Role of Arthrospira platensis Nanoparticles in Induced Testicular Damage in Male Rats
Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 25, Issue 1, May 2026, Pages 37-44 PDF (655.24 K)
Document Type: Research Paper
DOI: 10.29079/qjvms.2025.167182.1154
Authors
adnan M jasimh^* ; Ahmed Samir Abukhomra
Department of Physiology, Biochemistry and Pharmacology College of Veterinary Medicine , Al-Qasim Green university
Abstract
This study was conducted at the College of Veterinary Medicine, Al-Qasim Green University. It was between October 2024 and March 2025 to evaluate the efficacy of Arthrospira platensis that encapsulated in chitosan nanoparticles to inspection the mitigating effect of phenyl hydrazine which induces testicular damage in adult male rats. Arthrospira platensis (AP) was procured from selzeal, British AP and was loaded onto chitosan nanoparticles, and the resulting formulation was optimized and characterized. The study involved 40 adult male rats, divided into four groups of 10 for each. The first group used as control (CG) received only normal saline. Rats of the all other three groups were injected intraperitonealy with 20 mg/kg BW phenylhydrazine (PHZ) to induce testicular damage. Rats in third group received 50 mg/kg BW Arthrospira platensis (AP) daily. Rats in fourth group received 50 mg/kg AP-NPS daily. At the end of the study, the blood of the rats was collected, and all the rats were sacrificed and the testes of them were harvested. The study concluded that the use of AP-NPS effectively treat the induced testicular damage in rats.
Keywords
AP-NPS; ROS; infertility; phycocyanin; chitosan

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The Protective Role of Arthrospira platensis Nanoparticles in Induced Testicular Damage in Male Rats