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The Effect of Berberine on the Histological Changes Induced by Methioninemia in Male Albino Rats | ||
| Al-Qadisiyah Journal of Veterinary Medicine Sciences | ||
| Volume 25, Issue 1, May 2026, Pages 52-62 PDF (1.49 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.29079/qjvms.2025.167397.1159 | ||
| Authors | ||
| Aula Zahwar* ; Aseel Sabour | ||
| Department of Biology, College of Education, University of Al-Qadisiyah, Iraq | ||
| Abstract | ||
| Berberine, an active component of the plant was used in the study to investigate its possible protective effect in ameliorating methionine-induced histopathological changes on male albino rat liver. Thirty-two (32) adult male albino rats, average age 12–16 weeks and body weight ranging from 200 to 300 g were included in the current work. The study was conducted at an animal’s house, Department of Biology, College of Education, University of Al-Qadisiyah. The animals were randomly divided into four groups of eight (8) rats as follows:Group 1 (G1): Eight animals as negative control group and food and water were available ad libitum throughout the experiment period. Group 2 (G2): Consisted of 8 animals treated by gavage with methionine (100 mg/kg/body weight), comprising the positive control group.Group 3 (G3): Consisted of 8 animals that received orally methionine at a dose of 100 mg/Kg body weight and berberine at a dose of 40 mg/kg bw by the same way as group II over the entire experimental period.Group 4 (G4): Consisted of 8 animals that received berberine orally at a dose of 40 mg/kg body weight for the entire period of the experiment. Doses were administered orally for eight weeks. After the experimental period was over, the liver and kidney tissues were excised and prepared for histological screening by hematoxylin and eosin staining. The control and berberine (?)-only groups exhibited regular hepatic and renal architecture with well-preserved cell arrangement. The methionine-treated rats, on the other hand, demonstrated severe pathologic changes including marked of macrovesicular hepatic steatosis and sinusoidal congestion fibrotic deposition as well as cystic renal dilation associated with tubular degeneration. Of particular importance, in the methionine and berberine groups, we observed only some mild hepatic steatosis and that tubular changes were limited, suggestive of strong protection.These results could indicate the capacity of berberine to alleviate methionine-induced tissue injury due to its antioxidant, anti-inflammatory, and metabolic modulatory effects. The results indicate that berberine may be a potential therapeutic compound for liver and kidney damage in hypermethioninemia. | ||
| Keywords | ||
| Berberine; Methioninemia; Liver; Kidney; Rats | ||
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