- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Hypoxia promotes cellular apoptosis in blood cells through P53 activation in patients with Diabetes | ||
| Al-Kunooze Scientific Journal | ||
| Volume 12, Issue 3, July 2026, Pages 31-45 PDF (983.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.36582/ksj.2026.170052.1034 | ||
| Authors | ||
| Azhar Abul Jabbar Ameen* 1; zyad abdulkadhim mazyed2; Suhyila Fadhil Ali2 | ||
| 1Basrah university \\\\College of Science | ||
| 2Biology\college of science\Basrah university\Basrah\Iraq | ||
| Abstract | ||
| Hyperglycemia in diabetes promotes Hypoxia leading to alterations in the cellular microenvironment, Hypoxia triggers adaptive cellular responses, that are largely regulated via a transcription factor called Hypoxia inducible factor 1 -alpha (HIF-1α),in addition Hypoxia influences cell death pathways through the stabilization of the tumor suppressor factor p53.Aims: this study aims to assess the impact of hypoxia inducible factor (HIF-1α) in regulating p53 signaling in those with type 2 diabetes in comparison with the control group. Whole blood samples were obtained from both diabetes and non-diabetic participants, followed by quantitative PCR (qPCR) to estimate the relative transcriptional levels of (HIF-1α and p53). The results showed a significant up regulation in the expression of HIF-1α and p53inpatientsrelative to the control group, Analysis of covariance (ANCOVA) revealed that the overall model for HIF-1α and P53 expression was statistically significant, while diabetes status, gender and body mass index (BMI) did not show significant in dependent effects. Additionally a notable positive correlation was observed between expression of HIF-1α and p53. The study illustrated that a potential impact of theHIF-1α signaling in inducing cellular apoptosis through the upregulating of p53, these results provide evidencethatHIF-1α and p53 may act as interconnected cellular markers and support further investigation in expanded cohorts. | ||
| Keywords | ||
| Cellular apoptosis; Hyperglycemia; Blood microenvironment; Diabetes mellitus; Hypoxia inducible factor | ||
|
Statistics Article View: 263 PDF Download: 101 |
||