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Effect of Hydrogen Peroxide on Autologous Cranioplasty in Rabbits | ||
| Al- Anbar Medical Journal | ||
| Volume 22, Issue 3, July 2026, Pages 166-170 PDF (9.66 M) | ||
| Document Type: Original articles | ||
| DOI: 10.33091/amj.2026.168100.2550 | ||
| Authors | ||
| Mustafa Mohammed Hadi* 1; Mohammed ayad Talaat Almeran2; Ahmed Allawi Obaed1; Sura Atallah Mahmoud1 | ||
| 1Department of Anatomy, College of Medicine, University of Mosul, Mosul, Iraq. | ||
| 2Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq. | ||
| Abstract | ||
| Background: Craniotomy is used to treat open depressed skull fractures, often leading to a skull defect requiring cranioplasty. An alternative technique involving immediate reinsertion of fractured bone after cleaning and disinfecting was tested in rabbits. Objectives: To evaluate autologous cranioplasty in treating open depressed skull fractures in rabbits, using 3% hydrogen peroxide to sterilize contaminated bone fragments before reimplantation. Materials and Methods: Four groups of local rabbits (3.1–4.5 kg, 3–5 months old), each with 4 animals, were examined after surgery. Group A was assessed at 1 week postoperative, Group B at 3 weeks, Group C at 6 weeks, and Group D served as a control with normal bone tissue for histological reference. Rabbits were euthanized under deep anesthesia, wounds were re-explored, and bone fusion was examined by microscope. Results: All treated groups differed from the control. Group A showed inflammation without regeneration. Group B demonstrated moderate tissue response and regeneration. Group C showed significant remodeling and new bone formation. Group D had matured, stable bone with no inflammation or healing activity. Conclusion: Hydrogen peroxide-treated bone fragments enhanced healing and graft integration after cranioplasty in rabbits. Group C exhibited the highest healing response, and the method reduced the need for foreign implants or repeated surgeries. | ||
| Keywords | ||
| Cranioplasty; Skull fracture; Hydrogen peroxide; Rabbit model; Bone healing | ||
| References | ||
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