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The Dual Antibacterial Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Intrinsic Antibacterial Activity and Modulation of Antibiotic Susceptibility in Bacteria from Otitis Media | ||
| Basrah Journal of Veterinary Research | ||
| Volume 25, Issue 2, June 2026, Pages 55-69 PDF (1.13 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvr.2026.169390.1285 | ||
| Author | ||
| Zainab Radhi* | ||
| university of Basrah | ||
| Abstract | ||
| Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for their anti-inflammatory, analgesic, and antipyretic properties. However, emerging evidence suggests that some NSAIDs also exhibit antimicrobial effects, which could be valuable in the era of increasing antibiotic resistance. This study evaluated the in vitro antibacterial activity of three commonly used NSAIDs—aspirin (acetylsalicylic acid), ibuprofen and diclofenac sodium, against pathogenic bacteria isolated from patients with otitis media. Also, results of antibiotic sensitivity of each of E. coli and Staphylococcus aureus that exposed to NSAIDs showed increase in diameter of inhibition of antibiotic used against NSAIDs exposed bacteria in comparison to control (no exposed bacteria) The present findings demonstrate that aspirin and ibuprofen exhibit significant antibacterial effects, particularly against Staphylococcus aureus , while diclofenac showed selective activity. These results suggest that certain NSAIDs may have adjunctive antimicrobial potential, warranting further investigation into their mechanisms and clinical applications. | ||
| Keywords | ||
| : NSAIDs; antibacterial activity; antibiotic resistance; otitis media | ||
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