Synthesis and characterization of new &beta;-lactam derived from sulfapyridine and study the effect of the synthesized compounds on isolated bacteria in Basrah government

Alasadi, Mustafa LUQMAN; Mustafa, Jalal Yaseen; Al-Masoudi, Wasfi Abood

doi:10.23975/bjvr.2026.169298.1287

	Synthesis and characterization of new β-lactam derived from sulfapyridine and study the effect of the synthesized compounds on isolated bacteria in Basrah government
Basrah Journal of Veterinary Research
Volume 25, Issue 2, June 2026, Pages 70-86 PDF (1.12 M)
Document Type: Research Paper
DOI: 10.23975/bjvr.2026.169298.1287
Authors
Mustafa LUQMAN Alasadi^* ¹; jalal yaseen mustafa¹; wasfi abood Al-Masoudi²
¹Department of public health, ,College of Veterinary medicine, University of Basrah, Iraq
²Department of Physiology, Pharmacology and Chemistry, College of Veterinary medicine, University of Basrah, Iraq
Abstract
β-lactam were prepared in two steps including the condensation of 4-amino-N-pyridin-2-ylbenzenesulfonamide (sulfa pyridine) with 2-Hdroxy naphthaldehyde to produce a Schiff base (MW1). The synthesized compound was reacted with chloroacetyl chloride in the presence of triethylamine to produce a new beta-lactam compound (MW2) with good yield. The synthesized compounds were characterized by infrared (IR), proton, and carbon-13 nuclear magnetic resonance spectroscopy. The synthesized compounds were tested as antibacterial agents using pathogenic bacteria isolated and identified by PCR for Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, and Escherichia coli. The results of the study proved that the synthesized compounds in this study have clear efficacy against the pathogenic organisms used compared to the standard antibiotic used (ceftriaxone, cefepime, and penicillin G). In other words, the prepared beta-lactam compound has a wide range of antibacterial activity.
Keywords
β -Lactam, Sulfa pyridine, 2-Hydroxy naphthalaldehyde, Schiff-base, Antibacterial activity

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