- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Therapeutic Potential of Ethanolic Extract of Moringa Oleifera Against Hypothyroidism-Induced Myocardial Ischemia in Male Rats | ||
| Basrah Journal of Veterinary Research | ||
| Volume 25, Issue 2, June 2026, Pages 136-150 PDF (790.54 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvr.2026.171256.1308 | ||
| Authors | ||
| Duha Ibrahim* 1; Ahlam Ali Abdul-Nabi2 | ||
| 1Ph.D student at university of basrah | ||
| 2physiological department- college of vet medicine- university of basrah- Basrah- IRAQ | ||
| Abstract | ||
| Background: Moringa oleifera gained its importance as a natural antioxidant due to its high content of phenolic compounds, such as flavonoids and phenolic acids. Aim: The present experience was designed to assess the ability of extract of moringa leaves to prevent cardiac infraction in male rats with hypothyroidism. Methodology: 30 male rats were distributed in 2 groups, healthy group 10 rats and hypothyroid 20 rats. Hypothyroid was induced by administering 1mg/ml propylthiouracil (PTU) in drinking water for two months. After confirmed thyroid deficiency induced by measuring thyroid function test, showing low thyroid hormones levels and high TSH, animals were distributed equally into three groups 10 rats each, as follows; first group (intact animals ) as negative control, rats were administered (1ml) of normal solution, second group (hypothyroidism untreated), as positive control, rats were administered (1ml) of PTU, third group (HYPO-MOE treated), rats treatment with MOE at a dose 300 mg/kg, the treatment continued for one month. Results: The oral administration of PTU resulted pronounced reduction in the levels of thyroid hormones concomitantly with significantly elevation in TSH and lipid profile concurrently with diminished in the level of HDL, also results revealed elevation in heart enzymes activity accompanied by elevation of troponin I associated with histological changes in myocardial architecture whereas the treatment with MOE resulted in improvement the thyroid function, lipid profile, cardiac biomarkers and restoration of cardiac architecture. | ||
| Keywords | ||
| Myocardial ischemia; Moringa oleifera; Hypothyroidism; lipid profile; troponin | ||
|
Statistics Article View: 316 PDF Download: 114 |
||