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Α-Amyrin Nanocapsules Effectiveness on Mitochondrial Biogenesis and Lipid Profile in Diabetic Male Rats | ||
| Basrah Journal of Veterinary Research | ||
| Volume 25, Issue 2, June 2026, Pages 191-205 PDF (749.42 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvr.2026.167578.1265 | ||
| Authors | ||
| Nawras Alwan* ; Hadier Kadium Abass1; Eman Aboud Luaibi2 | ||
| 1Department of Basic Science, Faculty of Dentistry, Al-Qadisyah University, Iraq | ||
| 2Basrah University, College of Veterinary Medicine, Department of Physiology, Pharmacology & Biochemistry, Basrah, Iraq | ||
| Abstract | ||
| alpha-amyrin have beneficial effects in metabolic disorders. This study focuses on investigating effect of alpha-amyrin capsules on glucose and glycemic index in male rats with globulinemia fed a high-intensity diet . The groups included: (A) normal control group, orally supplied with drinking water; (B) a glucose group, in which streptozotocin was administered via glucose injection on a high-intensity diet; (C) a glucose group + شمحاش-amyrin (100 mg/rat daily dose) for one month on a high-intensity diet; (D) a glucose group + alpha-amyrin nanocapsule (50 mg/rat daily), in which rats were treated for one month on a high-intensity diet; (E) a glucose group + alpha-amyrin nanocapsule (40 mg/rat daily); and (F) a glucose group + alpha-amyrin nanocapsule (80 mg/rat daily). Following the induction of diabetes with a high-dose diet, rats were administered daily for one month. Group 7 (G) consisted of rats with diabetes and insulin (4 surgical units/rat subcutaneously). Significant improvements in glucose levels were observed in both the alpha-amyrin nanoparticle group (80 mg/kg) and the insulin group. A significant reduction in performance was also noted in Group F and the control NRF group compared to the other groups. Furthermore, plasma insulin levels and pancreatic histological analysis revealed that alpha-amyrin plays a role in maintaining beta cell integrity. GLUT4 expression (by qPCR) was also shown to be higher in the alpha-amyrin 40 group compared to the control group. conclude to which represent a novel approach for alpha-amyrin nanoparticles as a compound with hypoglycemic and lipid-lowering effects. | ||
| Keywords | ||
| α -amyrin; nanocapsule , hypolipidemic | ||
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