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Evaluation of IL-17 as an Inflammatory Marker in Patients with Hypothyroidism and Low Vitamin D Levels | ||
| Al-Zahraa Journal for Health and Medical Sciences | ||
| Volume 4, Issue 2, June 2026, Pages 84-94 PDF (634.17 K) | ||
| Document Type: Research Article | ||
| DOI: 10.66723/zjhms.2026.171680.1147 | ||
| Author | ||
| Teeba Fares Hadi* | ||
| Institute of Genetic Engineering and Biotechnology for postgraduate studies, University of Baghdad, Baghdad, Iraq | ||
| Abstract | ||
| Hypothyroidism is defined as the inability of the thyroid gland to produce sufficient hormones Interleukin-17 (IL-17) plays a crucial role in the development of hypothyroidism by promoting inflammation and modulating immune responses. This study aimed to evaluate the concentration of certain cytokines, including IL-17, and the low serum vitamin D levels in Iraqis with hypothyroidism. The study included 65 male and female participants (58.4% female and 41.5% male) aged 25–57 years, as well as 30 healthy individuals of varying ages. After a 12–14 hour fast, blood samples were collected to assess serum IL-17 levels using an ELISA assay. The results revealed an increased concentration of interleukin-17 in patients (13.53 ± 3.05) compared to the control group (10.31 ± 1.06). Vitamin D levels were also significantly decreased in patients (15.4 ± 2.15), suggesting that vitamin D deficiency may contribute to the elevated interleukin-17 levels, as pro-inflammatory cytokines are believed to play a role in the mechanism of hypothyroidism. The results also showed a significant increase in FT3, FT4levels, with a mean serum FT3 level of 4.12 ± 0.31 pmol/L in patients and 3.21 ± 1.05 pmol/L in healthy individuals. While mean serum free thyroid hormone (FT4) level in patients was 3.61 ± 1.17 pmol/L, compared with 2.06 ± 2.42 pmol/L in healthy individuals. A significant increase in thyroid-stimulating hormone (TSH) concentration were also observed., while the mean thyroid-stimulating hormone (TSH) level in patients was 9.20 ± 0.30 mIU/L, compared with 0.42 ± 0.56 mIU/L in healthy individuals. | ||
| Keywords | ||
| pro-inflammatory cytokines; IL-17; IL-6; Hypothyroidism; vitamin D | ||
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