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The role of TGF-Beta in diabetic nephropathy | ||
| Al-Qadisiyah Journal of Pure Science | ||
| Volume 31, Special, July 2026 PDF (660.46 K) | ||
| Document Type: IAAQC Conference | ||
| DOI: 10.29350/qjps.2026.170893.1075 | ||
| Authors | ||
| Ahmed Issa Almossawi* 1; Wejdan Thamir Mahdi2 | ||
| 1العراق/جامعة القادسية /كلية العلوم /قسم علوم الحياة | ||
| 2العراق، جامعة القادسية، كلية العلوم، قسم علوم الحياة | ||
| Abstract | ||
| This study aimed to evaluate the role of a panel of biomarkers, including TGF-β1, IL-6, mTOR, and total antioxidants, in the development of diabetic nephropathy, alongside traditional biochemical markers. The study included 100 participants: 50 patients with type 2 diabetes and 50 healthy individuals as a control group. The results showed elevated levels of HbA1c, creatinine, TGF-β1, IL-6, and mTOR in the patients compared to the healthy individuals, while albumin, antioxidant, and eGFR levels were decreased. These findings suggest that increased TGF-β1 and mTOR, along with impaired antioxidant defenses, play a significant role in the development of diabetic nephropathy, and that elevated IL-6 contributes to the promotion of inflammation associated with the disease. | ||
| Keywords | ||
| diabetic nephropathy,TGF-β 1, interleukin-6 (IL-6) | ||
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