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Phytochemical profiling and in vitro antimicrobial activity of selected Centaurea L. species extracts against multidrug-resistant pathogens | ||
| Journal of Medicinal and Industrial Plant Sciences | ||
| Volume 4, Issue 2, June 2026, Pages 87-98 PDF (610.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.32894/MEDIP.26.4.2.9 | ||
| Authors | ||
| Kwestan Kwbad Anwar* ; Sirwan Hassan Salih* | ||
| Department of Biology, College of Science, University of Sulaimani . Sulaimani, Kurdistan Region-Iraq. | ||
| Abstract | ||
| Species belonging to the genus Centaurea L. (Asteraceae) are recognized for their richness in secondary metabolites and diverse biological activities. Preliminary phytochemical screening in this present investigation of major natural product groups, particularly terpenes and flavonoids. The antimicrobial property of Centaurea hyalolepis Boiss. and Centaurea iberica Trevir.ex Spreng. leaf extracts were investigated. Plant material was extracted via maceration (MAC) using methanol %80, and antimicrobial activity was measured using agar well diffusion method against Escherichia coli, MDR Staphylococcus aureus and Candida albicans ATCC. Four extract concentrations (100mg/ml, 200mg/ml, 300mg/ml, 400mg/ml) were prepared using 5% Dimethyl sulfoxide as solvent. The result demonstrated that C.hyalolepis exhibited notable antibacterial and antifungal activities, with inhibition zones reaching 28 mm against Escherichia coli and MRD Staphylococcus aureus and 23 mm against C. albicans at highest concentration (400 mg/ml). Both species showed antibacterial effects. Among the tested samples; C. iberica showed the strongest antibacterial efficacy against MRD S. aureus, yielding an inhibition zone reached 33 mm at 400 mg/ml. In conclusion, these findings suggest that both species represent promising sources of natural antimicrobial agents, particularly due to their pronounced activity against multidrug-resistant S. aureus | ||
| Keywords | ||
| Antimicrobial activity; plant extraction; growth inhibition; multidrug-resistant | ||
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