Serum levels of Interleukin 6 and Homocysteine in Type 2 Diabetic Patients with renal failure complication

Hassan Abdul Jalil, Firyal; Zahraw Nada, Shaymaa

	Serum levels of Interleukin 6 and Homocysteine in Type 2 Diabetic Patients with renal failure complication
Kerbala Journal of Medicine
Article 7, Volume 3, Issue 6, 2010, Pages 804-811 PDF (0 K)
Authors
Firyal Hassan Abdul Jalil; Shaymaa Zahraw Nada
Abstract
ackground: Cardiovascular diseases are more common among type 2 diabetic patients than healthy subjects without a family history of diabetes. Serum interleukin-6 (IL-6) and homocysteine (Hcy) levels are markers of endothelial dysfunction and cardiovascular disease. Aim: this study demonstrated to evaluate levels of IL-6, Hcy and their association with cardiovascular risk in type 2 diabetic patients with renal failure complication. Material & Methods: The circulating IL-6 and Hcy levels were measured in 45 type 2 diabetic patients and 25 control subjects without a known family history of diabetes. The BIOSOURCE IL-6 ELISA kit used to measure IL- 6, high performance liquid chromatography HPLC technique used to measure serum Homocystein, and enzymatic methods are used for blood suger, urea, creatinine, and lipid profile measurements. Results: A significant differences were found in serum levels of IL6 and Hcy between the two groups diabetic and healthy control (p>0.05). IL6 levels correlated significantly with Hcy (p=0.02), hemoglobin A1C (p=0.03), and serum Hcy correlated significantly with HbA1C (p=0.03) levels in patients with type 2diabetes mellitus. Conclusion: These results suggest that serum IL-6 and Hcy levels do not directly contribute to the development of endothelial dysfunction and cardiovascular risk factors in type 2 diabetic patients with renal failure complication.

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