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Obestatin and neuropeptide Y as potential biomarkers of obesity in Iraqi obese males | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 20, Issue 2, August 2026, Pages 162-171 PDF (1.54 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2025.162610.1511 | ||
| Authors | ||
| Omar Zuhair Naji1; Othman R Al Samarrai* 2 | ||
| 1Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq | ||
| 2Department of Chemistry, College of Education, University of Samara | ||
| Abstract | ||
| Obesity is an escalating health problem in developing countries and represents a major global public health concern associated with increased morbidity and mortality. This study aimed to evaluate obestatin, adipsin, and neuropeptide Y as potential biomarkers of obesity in men and to assess their diagnostic performance using receiver operating characteristic (ROC) curve analysis. The study included 90 male participants from Samarra city, who were divided according to body mass index into normal-weight control, overweight, and obese groups. The results showed that obestatin and glutathione levels were significantly decreased in overweight and obese individuals compared with normal-weight controls (p ≤ 0.05). In contrast, adipsin, neuropeptide Y, and malondialdehyde levels were significantly higher in overweight and obese individuals. Total cholesterol, triglycerides, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and glucose levels were also elevated in the overweight and obese groups compared with the normal-weight group. ROC curve analysis showed strong diagnostic performance for the studied biomarkers. Obestatin achieved 100% sensitivity and 86.7% specificity, whereas neuropeptide Y showed excellent diagnostic accuracy, with both sensitivity and specificity reaching 100%. The present study concluded that obestatin levels were lower, while adipsin, neuropeptide Y, and malondialdehyde levels were higher in overweight and obese individuals than in normal-weight controls. These findings suggest that obestatin, adipsin, and neuropeptide Y may serve as promising biomarkers for obesity. | ||
| Keywords | ||
| Adipsin; neuropeptide Y; obesity; obestatin | ||
| References | ||
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