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The Relationship Between HLA-G and Oral Cancer | ||
| The Medical Journal of Basrah University | ||
| Article 7, Volume 44, Issue 1, July 2026, Pages 53-64 PDF (236.35 K) | ||
| Document Type: Review Paper | ||
| DOI: 10.33762/mjbu.2026.170849.1357 | ||
| Authors | ||
| Raghed Mohammed Jassem1; Hibbat Al-Rahman Riyadh Recad* 2; Zahra Kazim Saeed3; Najwan Sadik Shareef3; Raed Taha Al-Neama4 | ||
| 1Medical microbiology/ college of dentistry/university of Basrah | ||
| 2Medical microbiology/College of Dentistry/Basrah University | ||
| 3Medical microbiology/college of dentistry/ university of Basrah | ||
| 4Medical microbiology/college of dentistry/university of Basrah | ||
| Abstract | ||
| The review was on the relationship between oral cancer and human leukocyte antigen G (HLA-G) in oral squamous cell carcinoma (OSCC). Oral cancer is one of the current problems of critical health concern due to its late diagnosis, rapidness of the disease progression, the treatment outcomes are not good, and the tumor may avoid the immune system. The other significant mechanism to prevent immune attack is by the expression of non-classical HLA-G, which is a type of MHC class I molecule with powerful immunosuppressive functions. The results of the studies always show that the rise of the levels of HLA-G in OSCC is related to advanced stages of the disease, metastasis to lymph nodes, reduction in the survival rate, and tumor aggressiveness. In addition, HLA-G expression is highly linked to the presence of regulatory T-cells, which supports the importance of the given factor in the development of an immunosuppressive tumor microclimate. Though the HLA-G therapies are still in their early stage, there are already a number of promising approaches, such as monoclonal antibodies, small-molecule inhibitors, RNA interference, nanoparticle-based drug delivery systems, and CAR-T cell therapy. | ||
| Keywords | ||
| HLA-G; Oral Cancer; OSCC; metastasis; prognosis | ||
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