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Glycemic control and serum lipid profile in type2 diabetic patients | ||
| The Medical Journal of Basrah University | ||
| Article 9, Volume 44, Issue 1, July 2026, Pages 88-95 PDF (219.9 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2026.173723.1367 | ||
| Authors | ||
| Ammar Yesar Alshamaa* 1; Mohameed Abd abdalhussein2 | ||
| 1specialist physician -internal medicine -Najaf health directorate. | ||
| 2prof of internal medicine /college of medicine, university of kufa | ||
| Abstract | ||
| Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Dyslipidemia is a common metabolic abnormality among patients with T2DM and contributes significantly to the development of cardiovascular disease. Glycated hemoglobin (HbA1c) is widely used as a marker of long-term glycemic control and may be associated with alterations in lipid parameters. Objective: To investigate the association between glycemic control, assessed by HbA1c, and lipid parameters in patients with type 2 diabetes mellitus. Patients and Methods: This retrospective study included 100 patients with T2DM aged 40–87 years who attended the Endocrinology Center at Al-Sader Medical City, Al-Najaf, Iraq, between January 1 and September 30. The mean age of the participants was 57.71 years, and the mean HbA1c level was 8.68%. Patients were classified according to glycemic control using an HbA1c cutoff value of 6.5%. Lipid profile parameters, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and non-HDL cholesterol, were evaluated. Results: Patients with HbA1c levels ≥6.5% demonstrated significantly higher serum triglyceride and VLDL-C levels compared with those with HbA1c levels <6.5% (p = 0.00023 and p = 0.00047, respectively). No statistically significant associations were observed between HbA1c and TC, LDL-C, HDL-C, or non-HDL cholesterol. Smoking status was not significantly associated with any lipid profile parameter. Conclusion: Poor glycemic control was significantly associated with elevated triglyceride and VLDL-C levels in patients with type 2 diabetes mellitus. These findings suggest that HbA1c may serve as a useful indicator for identifying diabetic patients at increased risk of hypertriglyceridemia and VLDL-C elevation. However, no significant relationship was observed between HbA1c and other lipid parameters. Further studies with larger sample sizes and prospective designs are recommended to confirm these findings and clarify the clinical utility of HbA1c as a predictor of dyslipidemia in patients with T2DM. | ||
| Keywords | ||
| type 2 diabetes mellitus; low density lipoprotein; total cholesterol; triglyceride; high density lipoprotein | ||
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