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Antitumor activity of Rheum ribes and Thymus syriacus in male albino mice | ||
| JOURNAL OF THI-QAR SCIENCE | ||
| Article 1, Volume 2, Issue 3, 2011, Pages 135-144 | ||
| Author | ||
| Abstract | ||
| Abstract To search for possible chemo preventive agents from natural resources, the aqueous extracts of Rhaum ribes (Rhubarb) and Thymus syriacus (Thyme) with the concentrations 1% , 5%, and 5%,7.5% respectively were used via drinking water for 25 weeks to test its inhibitory role on skin tumors of male Swiss albino mice initiated with applied 7,12-dimethylbenz(a)anthracene (DMBA) on the dorsal skin ,mice were promoted by twice weekly application of benzoyl peroxide for 25 weeks .At the end of the experiment the animals were sacrificed and sections of skin were histologically studied.The result revealed that both plant extracts showed significant reduction in the number of mouse with tumors (incidence) and the number of tumors per mouse (multiplicity ) induced by DMBA .Histological investigations indicated that rhubarb extract reduced squamous papillomas and stimulated hair follicle proliferation .Thyme extracts also reduced squamous papillomas .these result suggest that rhubarb root and thyme leaves extract might be valuable as chemo preventive agent for chemical carcinogenesis.Key Words: Chemotherapy , Rhaum ribe Thymus syriacus Antitumor | ||
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