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Effect of Paracetamol and caffeine in structure and function of thyroidgland in male rats | ||
| Journal of College of Education for Pure Science | ||
| Article 1, Volume 1, Issue 5, 2011, Pages 89-102 | ||
| Author | ||
| Ihsan Raisan Ibrahim | ||
| Abstract | ||
| Paracetamol is a widly used drug as analgesic and antibyretic, also caffeine is a widly consumed as substance found in coffee, black tea ,green tea and cocoa. This study designed to know the effect of caffeine and paracetamol in the thyroid activity.Thirty six male rats randomly divided to six groups, first group considered as a control group, second group was given paracetamol at dose 500mg /kg .Third and fourth groups were given caffeine at dose 7.5mg/kg and 14 mg/kg of body weight respectively,while fifth and sixth groups were given paracetamol at dose 500mg/kg to both groups and caffeine was given at doses 7.5 mg/kg and 14 mg/kg to both groups respectively. In the and of treatment period animals were weighed and blood samples collected for determination T3,T4 and TSH levels , livre enzymes (GPT,GOT and ALP), creatinine and urea. Thyroid gland was removed for histological preparation, histological study involved the height of follicular cell and diameter of thyroid follicle. . Results showed that in both groups treated with caffeine (groups C1 and C2)significant increase occured in levels of T3 and T4 in addition to non- significant increase in TSH as compard with the control group inconstant there was significant decrease in T3,T4 and TSH in group treated with paracetamol ( grpup P) compared with the control group. In histological study results recorded significant increase in diameter of thyroid follicle in group treated with caffeine at dose 14 mg/kg(groupC2) compared with control group ,while there was significant increase in group P compared with P,PC1,PC2 and control groups . Statistical analysis showed significant decrease in GPT,GOT,ALP creatinine and urea levels in group C1 and C2 compared with control group,while threre was heigh significant increase in these levels in group P compared with other groups. It was concluded that administration of caffeine with paracetamol decrease the effects of paracetamol on thyroid gland activity and some biochemical parameters. | ||
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