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Role of olive oil in inhibition effect genotoxic of chloroform on the white mouse Mus musculus | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 11, Issue 1, 2011, Pages 21-28 | ||
| Abstract | ||
| The study was conducted in the time period between the month of November 2009 and January 2010 for the males of laboratory mice, white-type Mus musculus strain Balb/c, to indicate the role of olive oil in the inhibition of the toxic effect of the genetic material by chloroform. The results showed changes chromosomal structure of moral was broken chromatid and centromere as well as changes chromosomal numerical full of mice injected with chloroform and concentration 0.035 and 0.070 mg / 25 gm of body weight compared with the control group and when (P<0.01), and the results showed that high concentration of Chloroform was more influential and was significant in the induction of chromosomal changes, compared with the low concentration (P<0.05). The other hand, the results showed the ability of olive oil on the reduction of moral proportion changes aberrations both types of structural and numerical, which induced formation of chloroform at a level (p<0.01). As well as the results showed that animals given olive oil for 8 days after being injected with chloroform the percentage of inhibition in the aberrations which significantly higher proportion of inhibition of chromosomal aberrations of animals that were given olive oil for 4 days after being injected with chloroform and at a level (p <0.01). | ||
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