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Serum Oxidant / Antioxidant Parameters in Asthma | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 2, Issue 132, 2016, Pages 44-45 | ||
| Authors | ||
| Abdul Karem Y. Jawad; Abdul Ghani M. Al Samarai; Amina H. Al Obaidi | ||
| Abstract | ||
| Numerous disturbances of antioxidant defense mechanisms have been described in asthma. The study was performed on asthmatic patients and healthy non asthmatic control subjects. A total of 127 asthmatic patients (64 symptomatic and 63 asymptomatic, 24 intermittent, 20 with either persistent atopic or persistent non atopic asthma. ) included in the study, and their age range was from 17 to 52 years, and compared to that in 50 healthy controls. Total antioxidant capacity (TAC) was significantly (P<0.0001) lower in asthmatic patients (897 ± 178 µmol/l) as compared to control subjects (1074 ± 207 µmol/l). In addition, TAC serum level was significantly correlated with disease severity. The serum level of malodialdehyde was increased in asthmatic patients compared with that seen in control subjects and correlated with disease severity. The oxidation index was higher in all asthma group (4.92), asymptomatic group (3.63) and symptomatic group (6.39) than in control group (2.08). Uric acid mean serum level was significantly (P<0.0001) lower in asthmatic patients (4.75 ± 1.13 mg/dl) as compared to control (5.71 ±1.13mg/dl) subjects. The mean value of serum albumin was significantly (P<0.0001) lower in asthmatic patients (3.64 ± 0.93 g/dl) than that in control (4.56 ± 0.95 g/dl) subjects. Bilirubin mean serum level was lower in asthmatic patients (0.78 ± 0.17 mg/dl) as compared to control subjects (0.80 ± 0.19 mg/dl). The mean value of lactate was significantly (P<0.0001) higher in asthmatic patients (153.07 ± 19.62 mg/l) than that in control (78.43 ± 23.88 mg/l) subjects. Atopy did not influence the level of oxidant and antioxidant markers that determined in this study in asthmatic patients. Although, lactate as oxidant marker was higher in asthmatic patients, while the antioxidants markers such as uric acid, albumin and bilirubin were lower in asthmatic patients. Asthma severity associated with the oxidant and antioxidant markers in serum of asthmatic patients. | ||
| Keywords | ||
| Serum Oxidant | ||
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