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Early detection of prostatic carcinoma using t- PSA | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 2, Issue 132, 2016, Pages 141-144 | ||
| Authors | ||
| Salam S. Ahmed; Akram J. Ahmed; Ali A. Saied | ||
| Abstract | ||
| The study attempt to elucidate the performance of serum prostate specific antigen (PSA) as a diagnostic tool for prostate cancer in a selected group of patients. Serum level of total PSA (t- PSA) was measured. The study sample was composed of 180 male patients with lower urinary tract symptoms, abnormal digital rectal examination and abnormal trans-rectal ultrasound. The patients were divided according to the histopathological findings of the excised tumor into 2 groups: Group (1): Patients with prostate carcinoma (PCa) includes 38 (21.1%) patients, Group (2): Patients with nodular benign hypertrophy of the prostate (NBHP) includes 142 (78.8%) patients, and Control Group (3): Includes 50 apparently healthy male without lower urinary tract Symptoms. A total PSA were measured in the serum before the patients do the operative excision of prostatic carcinoma in Al-Zahrawi Teaching Hospital in Mosul. A comparison among the three groups revealed a significant difference in serum t-PSA between group 1 (PCa) and group 3 (control) and between group 1 (PCa) and group 2 (NBHP) (P < 0.01) with higher serum t-PSA mean values in group 1 (PCa) whereas a nonsignificant difference between group 2 (NPHP) and group 3 (control), (P > 05). Validity parameters of the serum total PSA were calculated at different cut-off values. At a cut-off value of 7 ng/ml, the sensitivity, specificity, positive predictive value, negative predictive value, accuracy rate, positive likelihood ratio, and negative likelihood ratio were 89%, 94%, 54%, 97%, 93%, 17.8%, and 9.4% respectively. Key words: prostate specific antigen, prostate cancer. | ||
| Keywords | ||
| Early detection of prostatic carcinoma using t; PSA | ||
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