The effect of the antidepressant drug imipramine on sodium blood level

Mahmood  AL-Saffar, Najat

	The effect of the antidepressant drug imipramine on sodium blood level
Medical Journal of Tikrit
Article 1, Volume 2, Issue 142, 2016, Pages 112-114
Author
Najat Mahmood AL-Saffar
Abstract
The effect of Antidepressant drug Imipramine on Sodium blood level was studied on 100 depressed patients treated with Imipramine drug for a period of from 0.5 to 5 years in a dose ranged from 75 to 150mg daily. Case series study. Psychiatric department at Ibn Seana Teaching Hospital, Mosul City for period from 0.5-5 years. 100 depressed patients 35 males and 65 females varying in age between 22-65 years mean 42.05+14.24 attending psychiatric unit Ibn-Seana hospital for treatment of depression with 100 normal (control) subjects were studied. The diagnosis of depression was based on the categories present in DSM-IV and ICD-10. Clinical examination and laboratory investigations for renal function for both groups were done which revealed normal and they were free of any known organic disease. Samples of blood were taken from both groups for estimation of serum sodium level; they were free of any medication at the time of sampling. Clinical examination for all patients revealed no symptoms of water intoxication, measurement of sodium blood level reported a range from 135-155 mM/L. Six patients reported low sodium blood levels 130-132 mM/L .There were no significant differences in sodium blood level among cases of depression and the control group which means the Antidepressant drug Imipramine has no or very little effect on sodium blood level. This study revealed that the uses of Antidepressant drug Imipramine for the treatment of depression has no or very little effect on sodium blood level
Keywords
The effect of the antidepressant drug imipramine on sodium blood level

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