EFFECT OF L-CARNITINE ON CERTAIN BIOCHEMICAL PARAMETERS IN DIABETIC PATIENTS

Abd Al-Monim Al-Farha, Manal; Yahya Dallal Bashi, Ahmed

	EFFECT OF L-CARNITINE ON CERTAIN BIOCHEMICAL PARAMETERS IN DIABETIC PATIENTS
Medical Journal of Tikrit
Article 1, Volume 1, Issue 161, 2012, Pages 146-151
Authors
Manal Abd Al-Monim Al-Farha; Ahmed Yahya Dallal Bashi
Abstract
To assess the effect of L-carnitine administration as an additional useful supplement, its modulating effect on glycaemic state, and its effect on certain parameters of renal function in type 2 diabetics with or without nephropathy. Patients and Methods: Fifty-four patients (32 males, 22 females) with type 2 diabetes mellitus who were attending Al-Waffa Diabetic Clinic, Mosul, Iraq; during the period from 1st October 2005 to 31st March 2006 were included in this study. L-carnitine was given to each of these diabetics for 45 days in a dose of 550 mg, in form of tablets in two doses orally, in addition to their other hypoglycaemic drugs. Blood samples were taken from each patient for the measurement of fasting plasma glucose (FPG), HbA1c, serum creatinine and urea before the first administration of L-carnitine, then after 15, 30 and 45 days from the commencement of the study. Mean FPG showed significant decrease (p<0.001) between the four intervals with a mean of 11.15 mmol/L before starting carnitine administration, 8.55 mmol/L after 15 days, 8.30 mmol/L after 30 days and 7.85 mmol/L after 45 days from the administration of carnitine. This study also shows a significant decrease in mean HbA1 and HbA1c when compared to that before administration (p<0.001) with mean of 8.99% and 6.78% respectively before starting administration, and 7.65% and 5.71% respectively 45 days after carnitine administration. Serum creatinine showed a significant decrease (p<0.001) with a mean of 114.9 µmol/L and 100.6 µmol/L before and 45 day from starting carnitine administration respectively. Serum urea showed also a significant decrease (p<0.01) from a mean of 6.61 mmol/L before carnitine administration and 6.03 mmol/L 45 days from starting carnitine administration. L-carnitine can be useful as an additional dietary supplement and pharmaceutical agent that complement other hypoglycaemic drugs for the management of type 2 diabetics. It has a lowering effect on fasting plasma glucose and blood HbA1c as well as its effect on improving renal function.
Keywords
Speaking scientific medical research on patients with diabetes Indicators chemical

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